An osteosarcoma-specific exosomal gene signature was developed using an orthotopic. xenograft model with a species-differentiating bioinformatics pipeline. The gene signature was validated in the serum of dogs with osteosarcoma, where it was able to detect minimal residual disease, and was therefore associated with prognosis following treatment.
- Kelly M. Makielski
- Alicia J. Donnelly
- Jaime F. Modiano
