Nature Search

The active site of magnesium chelatase

The insertion of magnesium into protoporphyrin starts the biosynthesis of chlorophyll. X-ray crystallography, computational modelling, mutagenesis and enzymology combined probe the magnesium chelatase complex’s structure and catalytic function.

Nathan B. P. Adams
Claudine Bisson
C. Neil Hunter
Research30 Nov 2020
Nature Plants

Volume: 6, P: 1491-1502
Realities of using self-administered smartphone surveys to solve sustainability challenges

Amy R. Lewis
Simon Willcock
Andrew R. Bell
ResearchOpen Access19 Jul 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-11
Genetic architecture of subcortical brain structures in 38,851 individuals

Genome-wide analysis identifies variants associated with the volume of seven different subcortical brain regions defined by magnetic resonance imaging. Implicated genes are involved in neurodevelopmental and synaptic signaling pathways.

Claudia L. Satizabal
Hieab H. H. Adams
M. Arfan Ikram
Research21 Oct 2019
Nature Genetics

Volume: 51, P: 1624-1636
The 2.4 Å crystal structure of the bacterial chaperonin GroEL complexed with ATPγS

David C. Boisvert
Jimin Wang
Paul B. Sigler
Research01 Feb 1996
Nature Structural Biology

Volume: 3, P: 170-177
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing

Analysis of whole-genome sequencing data across 2,658 tumors spanning 38 cancer types shows that chromothripsis is pervasive, with a frequency of more than 50% in several cancer types, contributing to oncogene amplification, gene inactivation and cancer genome evolution.

Isidro Cortés-Ciriano
Jake June-Koo Lee
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 331-341
CD3-negative natural killer cells express ε TCR as part of a novel molecular complex

Paul Anderson
Michael Caligiuri
Stuart F. Schlossman
Research14 Sept 1989
Nature

Volume: 341, P: 159-162
Heterotransplantation of Cultured Cell Lines in Newborn Hamsters treated with Antilymphocyte Serum

ROSLYN WALLACE
PAUL J. VASINGTON
JOHN C. PETRICCIANI
Research16 Apr 1971
Nature

Volume: 230, P: 454-455
Mutation of key signaling regulators of cerebrovascular development in vein of Galen malformations

Vein of Galen malformations (VOGMs) are severe congenital brain arteriovenous malformations. Here the authors work to elucidate the pathogenesis of VOGMs by performing an integrated analysis of 310 VOGM proband family exomes and 336,326 human cerebrovasculature single-cell transcriptomes to identify mutations of key signaling regulators.

Shujuan Zhao
Kedous Y. Mekbib
Kristopher T. Kahle
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-23
Genome-wide association analysis provides insights into the molecular etiology of dilated cardiomyopathy

Genome-wide association analyses comprising 14,256 cases and 1,199,156 controls and incorporating correlated cardiac magnetic resonance imaging traits provide insights into the molecular etiology of dilated cardiomyopathy.

Sean L. Zheng
Albert Henry
R. Thomas Lumbers
ResearchOpen Access21 Nov 2024
Nature Genetics

Volume: 56, P: 2646-2658
Travel surveillance uncovers dengue virus dynamics and introductions in the Caribbean

Dengue is a major public health concern in the Americas, and the Caribbean can be a source for reintroduction and spread. Here, the authors use travel surveillance data and genomic epidemiology to reconstruct Dengue epidemic dynamics in the Caribbean from 2009-2022.

Emma Taylor-Salmon
Verity Hill
Nathan D. Grubaugh
ResearchOpen Access25 Apr 2024
Nature Communications

Volume: 15, P: 1-14
Transverse emittance reduction in muon beams by ionization cooling

Current muon beams have a phase-space volume that is too large for applications in muon colliders. Now, the reduction in the beam’s transverse emittance when passed through different absorbers in ionization cooling experiments is quantified.

M. Bogomilov
R. Tsenov
C. Heidt
ResearchOpen Access17 Jul 2024
Nature Physics

Volume: 20, P: 1558-1563
Drosophila genes Posterior Sex Combs and Suppressor two of zeste encode proteins with homology to the murine bmi-1 oncogene

Brian P. Brunk
Elisabeth C. Martin
Paul N. Adler
Research26 Sept 1991
Nature

Volume: 353, P: 351-353
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

Si Lok
Kenneth Kaushansky
Donald C. Foster
Research16 Jun 1994
Nature

Volume: 369, P: 565-568
Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Different functional variants in ADH1B (and elsewhere) in Europeans and Africans strongly affect risk for alcohol dependence. Dependence only partly genetically correlates with consumption, with strong correlations to other psychiatric disorders.

Raymond K. Walters
Renato Polimanti
Arpana Agrawal
Research26 Nov 2018
Nature Neuroscience

Volume: 21, P: 1656-1669
Late Quaternary lake levels in southern Afar and the adjacent Ethopian Rift

M. A. J. WILLIAMS
PAUL M. BISHOP
R. GILLESPIE
Research01 Jun 1977
Nature

Volume: 267, P: 690-693
Histones in fixed cytological preparations of Chinese hamster chromosomes demonstrated by immunofluorescence

LILLIAN POTHIER
JOHN F. GALLAGHER
PAUL R. LIBBY
Research22 May 1975
Nature

Volume: 255, P: 350-352
Decoupled form and function in disparate herbivorous dinosaur clades

Stephan Lautenschlager
Charlotte A. Brassey
Paul M. Barrett
ResearchOpen Access20 May 2016
Scientific Reports

Volume: 6, P: 1-10
Mutations in the PTS1 receptor gene, PXR1, define complementation group 2 of the peroxisome biogenesis disorders

Gabriele Dodt
Nancy Braverman
Stephen J. Gould
Research01 Feb 1995
Nature Genetics

Volume: 9, P: 115-125
Genetic mechanisms of critical illness in COVID-19

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Erola Pairo-Castineira
Sara Clohisey
J. Kenneth Baillie
Research11 Dec 2020
Nature

Volume: 591, P: 92-98
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Computed redox potentials and the design of bioreductive agents

Christopher A. Reynolds
Paul M. King
W. Graham Richards
Research07 Jul 1988
Nature

Volume: 334, P: 80-82
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Environmental stress mediates groundwater microbial community assembly

A field investigation at a former nuclear waste disposal site shows how environmental stress modulates subsurface microbial community assembly.

Daliang Ning
Yajiao Wang
Jizhong Zhou
Research11 Jan 2024
Nature Microbiology

Volume: 9, P: 490-501
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Butler enables rapid cloud-based analysis of thousands of human genomes

Efficient, large-scale genomic analysis is facilitated on the cloud by a computational tool with error-diagnosing and self-healing capabilities.

Sergei Yakneen
Sebastian M. Waszak
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Biotechnology

Volume: 38, P: 288-292
IL-28, IL-29 and their class II cytokine receptor IL-28R

Paul Sheppard
Wayne Kindsvogel
Kevin M. Klucher
Research02 Dec 2002
Nature Immunology

Volume: 4, P: 63-68
Ultrafast carotenoid to pheophorbide energy transfer in a biomimetic model for antenna function in photosynthesis

Michael R. Wasielewski
Paul A. Liddell
Devens Gust
Research07 Aug 1986
Nature

Volume: 322, P: 570-572
Dopamine activation of the arachidonic acid cascade as a basis for D₁D₂ receptor synergism

Daniele Piomelli
Catherine Pilon
Jean-Charles Schwartz
Research12 Sept 1991
Nature

Volume: 353, P: 164-167
Earth in motion

Paul Segall
Books & Arts18 Nov 1993
Nature

Volume: 366, P: 222
Collagen genes

Paul Tolstoshev
Ellen Solomon
News & Views16 Dec 1982
Nature

Volume: 300, P: 581-582
Bacteriophage-antibiotic combination therapy against extensively drug-resistant Pseudomonas aeruginosa infection to allow liver transplantation in a toddler

In this study, authors use combinatory bacteriophage-antibiotic therapy, as treatment for extensively drug-resistant Pseudomonas aeruginosa infection in a toddler post liver transplantation. They report on the clinical and microbiological improvement, and present their investigation on how bacterial phage resistance did not result in therapeutic failure.

Brieuc Van Nieuwenhuyse
Dimitri Van der Linden
Jean-Paul Pirnay
ResearchOpen Access29 Sept 2022
Nature Communications

Volume: 13, P: 1-12
BRD4-mediated repression of p53 is a target for combination therapy in AML

MDM2 and BET inhibitors have shown efficacy in AML treatment. Here, the authors show that the two compounds can synergize through both p53 protein stabilization and inhibition of BRD4-mediated repression of p53 target genes.

Anne-Louise Latif
Ashley Newcombe
Peter D. Adams
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-16
Dissecting the catalytic triad of a serine protease

Paul Carter
James A. Wells
Research07 Apr 1988
Nature

Volume: 332, P: 564-568
Possible Rubidium–Iron Covariance in Potassium Feldspars

GALE K. BILLINGS
PAUL C. RAGLAND
J. A. S. ADAMS
Research21 May 1966
Nature

Volume: 210, P: 829-830
Author Correction: The evolutionary history of 2,658 cancers

Moritz Gerstung
Clemency Jolly
Christian von Mering
Amendments and CorrectionsOpen Access25 Jan 2023
Nature

Volume: 614, P: E42
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
Comprehensive molecular characterization of mitochondrial genomes in human cancers

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Yuan Yuan
Young Seok Ju
Christian von Mering
ResearchOpen Access05 Feb 2020
Nature Genetics

Volume: 52, P: 342-352
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Dynamic regulation of T_FH selection during the germinal centre reaction

T follicular helper cells undergo antigen-dependent selection in germinal centres, with higher-affinity T cell receptors supporting stronger proliferation leading to their clonal dominance.

Julia Merkenschlager
Shlomo Finkin
Michel C. Nussenzweig
Research03 Feb 2021
Nature

Volume: 591, P: 458-463
C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

Donor-specific antibodies in sensitized recipients may cause kidney transplant rejection. Here the authors show that complement component C3 inhibition prolongs graft survival by inhibiting T and B cell proliferation/activation and hence tissue injury, despite antibody levels remaining unaffected.

Robin Schmitz
Zachary W. Fitch
Stuart J. Knechtle
ResearchOpen Access15 Sept 2021
Nature Communications

Volume: 12, P: 1-11
Observation of the antimatter hypernucleus \({}_{\bar{{\boldsymbol{\Lambda }}}}{}^{{\bf{4}}}\bar{{\bf{H}}}\)

An antimatter hypernucleus formed by an anti-lambda hadron, an antiproton and two antineutrons was observed through its two-body decay after production in ultrarelativistic heavy-ion collisions.

M. I. Abdulhamid
B. E. Aboona
M. Zyzak
Research21 Aug 2024
Nature

Volume: 632, P: 1026-1031
Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

Here the authors characterise the cellular and molecular progression of lung alveolar damage in severe COVID-19 patients using integrated histopathology and cell atlassing, pinpointing a role for macrophage SPP1 signalling to vasculature in this process.

Jimmy Tsz Hang Lee
Sam N. Barnett
Omer Ali Bayraktar
ResearchOpen Access10 Mar 2025
Nature Communications

Volume: 16, P: 1-16
Distinct pools of synaptic vesicles in neurotransmitter release

Vincent A. Pieribone
Oleg Shupliakov
Paul Greengard
Research08 Jun 1995
Nature

Volume: 375, P: 493-497
Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes

Anthony Bahinski
Angus C. Nairn
David C. Gadsby
Research31 Aug 1989
Nature

Volume: 340, P: 718-721
Large-scale solar-wind structure near the Sun detected by Doppler scintillation

Richard Woo
Paul Gazis
Research09 Dec 1993
Nature

Volume: 366, P: 543-545
Evidence for an essential non-Watson–Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron

Roy Parker
Paul G. Siliciano
Research18 Feb 1993
Nature

Volume: 361, P: 660-662
Molecular characterization of single memory B cells

Michael G. McHeyzer-Williams
G. J. V. Nossal
Paul A. Lalor
Research11 Apr 1991
Nature

Volume: 350, P: 502-505
Imaging quantized vortex rings in superfluid helium to evaluate quantum dissipation

Quantum vortices exist in superfluid and play important role in superfluid characteristics. Here the authors determine quantum dissipation caused by mutual friction in superfluid by filming the motion of quantized vortex rings in superfluid helium.

Yuan Tang
Wei Guo
Toshiaki Kanai
ResearchOpen Access23 May 2023
Nature Communications

Volume: 14, P: 1-8
Association between polygenic risk for Major Depression and brain structure in a mega-analysis of 50,975 participants across 11 studies

Xueyi Shen
Yara J. Toenders
Greig de Zubicaray
ResearchOpen Access19 Aug 2025
Molecular Psychiatry

P: 1-11
A retrograde co-orbital asteroid of Jupiter

Asteroid 2015 BZ₅₀₉ is a retrograde co-orbital asteroid of the planet Jupiter, stably orbiting in a sense opposite to that of Jupiter’s orbit around the Sun for around a million years.

Paul Wiegert
Martin Connors
Christian Veillet
Research30 Mar 2017
Nature

Volume: 543, P: 687-689

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