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Showing 1–6 of 6 results
Advanced filters: Author: Paul H. Krebsbach Clear advanced filters

  • Although human pluripotent stem cells (hPSCs) can be used to regenerate neural tissues, inefficient protocols and poorly defined culture conditions have hindered their use. It is now shown that soft, micropatterned culture substrates can induce hPSCs to differentiate into motor neurons with significantly improved yields and purity in comparison to rigid substrates, and that such mechanotransductive process involves the Hippo/YAP pathway and phosphorylation of the intracellular protein Smad.

    • Yubing Sun
    • Koh Meng Aw Yong
    • Jianping Fu
    Research
    Nature Materials
    Volume: 13, P: 599-604

  • The development of fully defined culture conditions for human embryonic stem cells (hESCs) should enhance experimental reproducibility, reduce unwanted contaminants and facilitate scale-up production. Villa-Diaz et al. show that a substrate made of the synthetic polymer PMEDSAH supports long-term culture of hESCs.

    • Luis G Villa-Diaz
    • Himabindu Nandivada
    • Gary D Smith
    Research
    Nature Biotechnology
    Volume: 28, P: 581-583

  • Cancer-associated fibroblasts promote tumour growth and metastasis by secreting signalling molecules. Jung and colleagues show that prostate cancer cells secrete CXC chemokine ligand 16, which recruits mesenchymal stem cells and converts them into cancer-associated fibroblasts.

    • Younghun Jung
    • Jin Koo Kim
    • Russell S. Taichman
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • It has been well shown that NF-κB has a crucial role in promoting the maturation of bone-resorbing osteoclasts. Now, Cun-Yu Wang and his colleagues show that it also has a role in inhibiting the function of mature bone-forming osteoblasts. They go on to show that deficiency of NF-κB specifically in osteoblasts increases bone formation and protects against bone loss in experimentally-induced osteoporosis in mice.

    • Jia Chang
    • Zhuo Wang
    • Cun-Yu Wang
    Research
    Nature Medicine
    Volume: 15, P: 682-689