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Showing 1–3 of 3 results
Advanced filters: Author: Paul Meraner Clear advanced filters

  • Here, a genome-wide CRISPR–Cas9 screen is used to identify the Wnt receptors frizzled as physiologically relevant Clostridium difficile toxin B receptors, providing new therapeutic targets for treating C. difficile infections.

    • Liang Tao
    • Jie Zhang
    • Min Dong
    Research
    Nature
    Volume: 538, P: 350-355

  • Store-operated calcium entry involves two proteins: Stim1 and Orai1, but are they sufficient for gating CRAC channels or are other factors required? Mammal systems have failed to provide a conclusive answer but yeast-based assay does: Stim1 and Orai1 are the only essential components of CRAC channel activity.

    • Yubin Zhou
    • Paul Meraner
    • Patrick G Hogan
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 112-116

  • In immune cells, CRAC channels in the plasma membrane regulate store-operated Ca2+ entry in response to STIM1, a sensor protein located in the endoplasmic reticulum (ER) membrane. New biophysical assays show how dimerization of STIM1's ER-luminal domains causes extension of its cytoplasmic domains toward the plasma membrane to contact the ORAI pore and activate the channel, revealing the structural dynamics of this Ca2+-signaling mechanism.

    • Yubin Zhou
    • Prasanna Srinivasan
    • Patrick G Hogan
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 973-981