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Showing 1–3 of 3 results

Advanced filters: Author: Paul V. Dellorusso Clear advanced filters

Stromal niche inflammation mediated by IL-1 signalling is a targetable driver of haematopoietic ageing

Mitchell et al. identify reduced osteoprogenitors and increased mesenchymal stromal cells in old bone marrow niche, which creates an IL1-mediated inflammatory milieu that skews myeloid differentiation and impairs haematopoietic regeneration.

Carl A. Mitchell
Evgenia V. Verovskaya
Emmanuelle Passegué
Research17 Jan 2023
Nature Cell Biology

Volume: 25, P: 30-41
Insights into ancestral diversity in Parkinson’s disease risk: a comparative assessment of polygenic risk scores

Paula Saffie-Awad
Spencer M. Grant
Sara Bandres-Ciga
ResearchOpen Access03 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-13
Dysregulated haematopoietic stem cell behaviour in myeloid leukaemogenesis

This Review outlines the ways in which leukaemic stem cells (LSCs) take advantage of normal haematopoietic stem cell properties to promote survival and expansion in myeloid leukaemogenesis. Opportunities for treatment of this disease by targeting LSC-specific mechanisms are also discussed.

Masayuki Yamashita
Paul V. Dellorusso
Emmanuelle Passegué
Reviews15 May 2020
Nature Reviews Cancer

Volume: 20, P: 365-382