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Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease

This study shows that brain connectivity changes in Huntington’s disease begin decades before symptoms, shifting from hyper- to hypoconnectivity, with links to specific neurotransmitter systems specially in granular and infragranular cortical layers.

Carlos Estevez-Fraga
Isaac Sebenius
Peter McColgan
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Lumbar puncture safety and tolerability in premanifest and manifest Huntington’s disease: a multi-analysis cross-sectional study

Yara Refaat Hassan
Filipe Brogueira Rodrigues
Sarah J. Tabrizi
ResearchOpen Access01 Nov 2022
Scientific Reports

Volume: 12, P: 1-11

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Cell-specific mechanisms drive connectivity across the time course of Huntington’s disease

Lumbar puncture safety and tolerability in premanifest and manifest Huntington’s disease: a multi-analysis cross-sectional study

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