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Showing 1–7 of 7 results
Advanced filters: Author: Paula V Welander Clear advanced filters

  • Lipoproteins are major cell-surface components in archaea, but their functions and the lipidation mechanisms are unclear. Here, Hong et al. identify two proteins required for attachment of proteins to unique archaeal membrane lipids via thioether bonds, and demonstrate their importance in archaeal physiology.

    • Yirui Hong
    • Kira S. Makarova
    • Mechthild Pohlschroder
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • Production of highly modified sterols, such as cholesterol, is essential to eukaryotic physiology but has not been yet reported for bacteria. Here, Lee et al. show that a marine myxobacterium produces cholesterol, and provide evidence for further downstream modifications in this and other bacterial species.

    • Alysha K. Lee
    • Jeremy H. Wei
    • Paula V. Welander
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-9

  • Sterane molecular fossils with side-chain methylations have not been reported in the bacterial domain. One such sterane, 24-isopropylcholestane, has been attributed to ancient sponges, potentially representing the earliest evidence for animals on Earth. This study demonstrates that symbiotic bacteria are capable of producing the 24-isopropyl sterol side-chain, suggesting that bacteria should not be dismissed as sources of these biomarkers in the rock record.

    • Malory O. Brown
    • Babatunde O. Olagunju
    • Paula V. Welander
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11

  • Lipid biomarkers provide insights into the nature and history of the Earth’s microbial life. In this Review, Summons et al. discuss how advances in molecular biology have helped elucidate lipid biomarker origins and afforded robust interpretations of fossil lipids, and explore key examples of how genomics-enabled advances in lipid biomarker science are illuminating the history of microbial life on the Earth.

    • Roger E. Summons
    • Paula V. Welander
    • David A. Gold
    Reviews
    Nature Reviews Microbiology
    Volume: 20, P: 174-185