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Showing 1–5 of 5 results
Advanced filters: Author: Paulius Grigaravicius Clear advanced filters

  • Cilia, tiny outgrowths of cells, are essential for life. Here, the author’s describe the scaffold protein TRIP6, which promotes the assembly of ciliary proteins required for ciliogenesis, and show that its absence results in hydrocephalus.

    • Shalmali Shukla
    • Ronny Haenold
    • Peter Herrlich
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Ataxia Telangiectasia and Rad3-related (ATR) is a key regulator of replication stress response; yet, mutations within the ATR gene cause human ATR-Seckel Syndrome associated with microcephaly and intellectual disability. Here, the authors show neuron-specific ATR deletion increases intrinsic neuronal and epileptiform activity, revealing a function of ATR beyond its role in DNA damage response.

    • Murat Kirtay
    • Josefine Sell
    • Zhao-Qi Wang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • DNA damage at stalled replication forks activates Chk1 kinase and poly(ADP-ribose) (PAR) polymerase 1. Min et al.find that retention of Chk1 to stalled replication forks depends on its direct interaction with PAR, and show that PAR chain length fine-tunes Chk1 and S-phase checkpoint activation.

    • WooKee Min
    • Christopher Bruhn
    • Zhao-Qi Wang
    Research
    Nature Communications
    Volume: 4, P: 1-14