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Showing 1–9 of 9 results
Advanced filters: Author: Pavel I. Kos Clear advanced filters

  • Using single-molecule tracking of cohesin and CTCF during zebrafish embryogenesis, the molecular kinetics underlying chromatin architecture formation was revealed and gradual emergence of chromatin structure recapitulated by polymer simulations.

    • Jonas Coßmann
    • Pavel I. Kos
    • J. Christof M. Gebhardt
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • The role of the nuclear lamina (NL) in chromatin architecture is still poorly understood. Here, the authors provide evidence that disruption of the NL in Drosophila cells leads to overall chromatin compaction and repositioning from the nuclear envelope, whereas lamina-associated regions become less compacted and transcription within them is increased.

    • Sergey V. Ulianov
    • Semen A. Doronin
    • Yuri Y. Shevelyov
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-11

  • Genomes are partitioned into topologically associating domains (TADs). Here the authors present single-nucleus Hi-C maps in Drosophila at 10 kb resolution, demonstrating the presence of chromatin compartments in individual nuclei, and partitioning of the genome into non-hierarchical TADs at the scale of 100 kb, which resembles population TAD profiles.

    • Sergey V. Ulianov
    • Vlada V. Zakharova
    • Sergey V. Razin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • Live-cell imaging shows that interactions within topologically associating domains are transient and frequent throughout the cell cycle. Convergent CTCF sites regulate the frequency and duration of interactions, which last a few minutes on average.

    • Pia Mach
    • Pavel I. Kos
    • Luca Giorgetti
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1907-1918

  • Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

    • Bin Zhou
    • Kate E. Sheffer
    • Majid Ezzati
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2885-2901

  • Venit et al. demonstrate a role for Nuclear myosin 1 (NM1) in the DNA Damage Response by affecting the expression of the p53 target, p21, through chromatin remodeling. They used embryonic fibroblasts from mouse model, high content phenotypic profiling and cell assays, RNA-Seq and ChIP-Seq and pull-down assays and show that NM1 is required for the recruitment of PCAF and SET1 to the p21 gene in response to etoposide.

    • Tomas Venit
    • Khairunnisa Semesta
    • Piergiorgio Percipalle
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-13