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Showing 1–3 of 3 results
Advanced filters: Author: Pawat Laohamonthonkul Clear advanced filters

  • Mutations in the coatomer complex I can result in endoplasmic reticulum stress and inflammatory consequences. Here authors define aberrant activation of the STING immunosensing pathway in a disturbed coatmer complex context and the therapeutic modulation of this axis to counter the associated immunopathology.

    • Annemarie Steiner
    • Katja Hrovat-Schaale
    • Seth L. Masters
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • This Review from Masters and colleagues highlights how damage to intracellular organelles is linked to activation of the innate immune system. The authors propose that a better appreciation of such organellar homeostasis could lead to the identification of novel innate immune pathways and have therapeutic implications.

    • Cassandra R. Harapas
    • Elina Idiiatullina
    • Seth L. Masters
    Reviews
    Nature Reviews Immunology
    Volume: 22, P: 535-549