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Showing 1–6 of 6 results
Advanced filters: Author: Pawel Fidzinski Clear advanced filters

  • Several K+ channels control neuronal excitability, but the function of KCNQ5 (Kv7.5), which displays wide expression in the brain, is not known. Here the authors show that KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.

    • Pawel Fidzinski
    • Tatiana Korotkova
    • Thomas J. Jentsch
    Research
    Nature Communications
    Volume: 6, P: 1-13

  • Whether and how slow wave activity (SWA) and the underlying membrane potential UP and DOWN states initiate mechanisms that augment memory functions in humans are not fully understood. Here authors used multineuron patch-clamp in alive human brain tissue, resected during neurosurgeries, to show that membrane potential UP/DOWN states, which mimic neural sleep activity, modulate axonal action potentials to boost synaptic strength and plasticity.

    • Franz X. Mittermaier
    • Thilo Kalbhenn
    • Jörg R. P. Geiger
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Calcium-activated chloride currents are thought to amplify the olfactory signal during the transduction process. Here the authors identify Ano2 as the critical channel in both main olfactory epithelium and in the vomeronasal organ. Surprisingly, disruption of Ano2 did not reduce performance in an olfactory behavioral task, suggesting that olfaction does not actually depend on these channels.

    • Gwendolyn M Billig
    • Balázs Pál
    • Thomas J Jentsch
    Research
    Nature Neuroscience
    Volume: 14, P: 763-769