Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors highlight the intra-tumour heterogeneity of this disease, finding that spatially closer tumour sectors are genetically more similar and that intra-hepatic metastasis is accompanied by rapid genetic diversification.
- Weiwei Zhai
- Tony Kiat-Hon Lim
- Pierce Kah-Hoe Chow
