Artificial assembly of small functional proteins provides effective strategies for downsizing RNA degraders. Here, authors develop STAR, a hypercompact RNA degrader with evolved toxin endoribonucleases and engineered Cas6- CBS system, enabling efficient degradation of cytoplasmic and nuclear RNAs.
- Pin-Ru Chen
- Pei-Pei Qin
- Bin-Cheng Yin
