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Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Gluconeogenesis is downregulated in hepatocellular carcinoma. Here, the authors show that nuclear receptor Nur77 acts as a tumour suppressor sustaining gluconeogenesis by enhancing phosphoenolpyruvate carboxykinase (PEPCK1) stability via regulating its interaction with the SUMO-conjugating enzyme Ubc9.

Xue-li Bian
Hang-zi Chen
Qiao Wu
ResearchOpen Access27 Feb 2017
Nature Communications

Volume: 8, P: 1-14
N4-acetylcytidine modification of lncRNA CTC-490G23.2 promotes cancer metastasis through interacting with PTBP1 to increase CD44 alternative splicing

Xiao-Mei Yu
Shu-Jun Li
Bin Li
Research16 Feb 2023
Oncogene

Volume: 42, P: 1101-1116
Piezo1 channel activation facilitates baroreflex afferent neurotransmission with subsequent blood pressure reduction in control and hypertension rats

Chang-peng Cui
Xue Xiong
Bai-yan Li
Research05 Sept 2023
Acta Pharmacologica Sinica

Volume: 45, P: 76-86
Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination

Huo-Liang Zheng
Wen-Ning Xu
Sheng-Dan Jiang
ResearchOpen Access15 May 2021
Cell Death & Disease

Volume: 12, P: 1-16
Preparing entangled states between two NV centers via the damping of nanomechanical resonators

Xiao-Xiao Li
Peng-Bo Li
Fu-Li Li
ResearchOpen Access26 Oct 2017
Scientific Reports

Volume: 7, P: 1-9

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