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Showing 1–2 of 2 results
Advanced filters: Author: Pengge Qian Clear advanced filters

  • The structure of subpellicular microtubules (SPMTs) nucleated from the apical polar ring (APR) is essential for Plasmodium parasite morphogenesis, gliding motility, and invasion. Here, Qian et al. characterize the function of APR2 protein in P. yoelii ookinetes. Using co-localization analysis, proximity labeling, CoIP, expansion microscopy and FRAP, they show that APR2 binds to SMPTs and has a fixed position in APR. Deletion mutants fail to traverse the mosquito midgut as they fail to anchor SPMTs on APR, which affects invasive morphology and gliding motility.

    • Pengge Qian
    • Xu Wang
    • Jing Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-23

  • Mosquito-derived xanthurenic acid (XA) is a trigger for gametogenesis of Plasmodium parasites. Here the authors show that the putative amino acid transporter GEP1 is required for XA-stimulated gametogenesis in Plasmodium yoelii and that it interacts with guanylyl cyclase α (GCα), a cGMP synthesizing enzyme in gametocytes.

    • Yuanyuan Jiang
    • Jun Wei
    • Jing Yuan
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15