Nature Search

Selective identification of epigenetic regulators at methylated genomic sites by SelectID

The authors introduce SelectID, an approach combining CRISPR-guided targeting with methylation-sensitive labeling to identify proteins interacting with methylated repetitive sequences. They suggest that CHD4 directly binds young LINE-1 retrotransposons, suppressing their activity.

Wenchang Qian
Penglei Jiang
Pengxu Qian
ResearchOpen Access18 Apr 2025
Nature Communications

Volume: 16, P: 1-14
SNORD113–114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery

Wang et al. profile the translatome of haematopoietic stem cells (HSCs) and downstream progenitors and lineages. They identify the SNORD113–114 cluster as a modulator of translation and self-renewal in HSCs.

Hui Wang
Zhaoru Zhang
Pengxu Qian
Research31 Jan 2025
Nature Cell Biology

Volume: 27, P: 246-261
Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis

Primary biliary cholangitis is a chronic autoimmune disease critically linked to immunological dysregulation but the local immune-pathogenesis is poorly understood. Here the authors present single cell transcriptomic characterisation of primary biliary cholangitis and implicates Th1 like cells in a murine model.

Ciliang Jin
Penglei Jiang
Yida Yang
ResearchOpen Access07 Oct 2024
Nature Communications

Volume: 15, P: 1-19
Grave-to-cradle photothermal upcycling of waste polyesters over spent LiCoO₂

The increasing production of lithium-ion batteries and plastics presents significant challenges to resource sustainability and ecosystem integrity. This study highlights the utilization of spent lithium cobalt oxide cathodes as photothermal catalysts to transform various waste polyesters into valuable monomers.

Xiangxi Lou
Penglei Yan
Jinxing Chen
ResearchOpen Access28 Mar 2024
Nature Communications

Volume: 15, P: 1-11
Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

DNA methyltransferase 3A, a mutated gene associated with hematologic malignancies in age-related clonal haematopoiesis lacks targeted therapies. Here, the authors screen carbon nanomaterials and find graphdiyne oxide binds to mutant cells and disrupts cellular processes with a therapeutic effect in vitro and in vivo.

Qiwei Wang
Ying Liu
Pengxu Qian
ResearchOpen Access26 Sept 2022
Nature Communications

Volume: 13, P: 1-16
PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus

Phc1 is a subunit of the polycomb repressive complex 1 (PRC1), which represses gene expression during development. Here the authors show that Phc1 acts independently from PRC1 to activate Nanog transcription by stabilizing genome-wide chromatin interactions of the Nanog locus, and in turn stabilize pluripotency.

Li Chen
Qiaoqiao Tong
Junfeng Ji
ResearchOpen Access14 May 2021
Nature Communications

Volume: 12, P: 1-13
Machine learning models predict risk of lower extremity deep vein thrombosis in hospitalized patients with spontaneous intracerebral hemorrhage

Weizhi Qiu
Penglei Cui
Yasong Li
ResearchOpen Access10 Jul 2025
Scientific Reports

Volume: 15, P: 1-12
Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia

Yang et al. report that the nucleolar protein fibrillarin (FBL) affects acute myeloid leukaemia (AML) cell function through biomolecular condensation-dependent regulation of early pre-rRNA processing and translation.

Lin Yang
Zhaoru Zhang
Pengxu Qian
Research14 May 2024
Nature Cell Biology

Volume: 26, P: 946-961
Uniformly dispersed platinum-cobalt alloy nanoparticles with stable compositions on carbon substrates for methanol oxidation reaction

Hui Liu
Chengyin Li
Jun Yang
ResearchOpen Access12 Sept 2017
Scientific Reports

Volume: 7, P: 1-8
MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Xiujian Wang
Xiao Tao
He Huang
ResearchOpen Access22 Oct 2024
Signal Transduction and Targeted Therapy

Volume: 9, P: 1-19
Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling

Tingting Yan
Chaoqin Shen
Jing-Yuan Fang
ResearchOpen Access19 Feb 2021
Signal Transduction and Targeted Therapy

Volume: 6, P: 1-13
Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy

Tao Yan
Xin Chen
Shiguang Zhao
ResearchOpen Access13 May 2021
Cell Death & Disease

Volume: 12, P: 1-15
Regulation of MYB by distal enhancer elements in human myeloid leukemia

Mengjia Li
Penglei Jiang
Junfang Zhang
ResearchOpen Access26 Feb 2021
Cell Death & Disease

Volume: 12, P: 1-14
A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90

Chen-Yang Yu
Ji-Xuan Han
Jing-Yuan Fang
ResearchOpen Access22 Oct 2019
Oncogene

Volume: 39, P: 1347-1360
Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3

Yamei Hu
Fangfang Liu
Kangdong Liu
Research13 May 2021
Oncogene

Volume: 40, P: 3942-3958
A clustering-optimized segmentation algorithm and application on food quality detection

QingE Wu
Penglei Li
Tao Zong
ResearchOpen Access05 Jun 2023
Scientific Reports

Volume: 13, P: 1-14
Branched Au Nanostructures Enriched with a Uniform Facet: Facile Synthesis and Catalytic Performances

Mingshan Zhu
Bin Lei
Minghua Liu
ResearchOpen Access11 Jun 2014
Scientific Reports

Volume: 4, P: 1-8

Search

Selective identification of epigenetic regulators at methylated genomic sites by SelectID

SNORD113–114 cluster maintains haematopoietic stem cell self-renewal via orchestrating the translation machinery

Single-cell RNA sequencing reveals the pro-inflammatory roles of liver-resident Th1-like cells in primary biliary cholangitis

Grave-to-cradle photothermal upcycling of waste polyesters over spent LiCoO₂

Graphdiyne oxide nanosheets display selective anti-leukemia efficacy against DNMT3A-mutant AML cells

PHC1 maintains pluripotency by organizing genome-wide chromatin interactions of the Nanog locus

Machine learning models predict risk of lower extremity deep vein thrombosis in hospitalized patients with spontaneous intracerebral hemorrhage

Phase separation-competent FBL promotes early pre-rRNA processing and translation in acute myeloid leukaemia

Uniformly dispersed platinum-cobalt alloy nanoparticles with stable compositions on carbon substrates for methanol oxidation reaction

MEK inhibition prevents CAR-T cell exhaustion and differentiation via downregulation of c-Fos and JunB

Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling

Interfering with hyaluronic acid metabolism suppresses glioma cell proliferation by regulating autophagy

Regulation of MYB by distal enhancer elements in human myeloid leukemia

A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90

Periplogenin suppresses the growth of esophageal squamous cell carcinoma in vitro and in vivo by targeting STAT3

A clustering-optimized segmentation algorithm and application on food quality detection

Branched Au Nanostructures Enriched with a Uniform Facet: Facile Synthesis and Catalytic Performances

Search

Quick links

Search

Filter By:

Search

Quick links