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Showing 1–2 of 2 results
Advanced filters: Author: Pengxin Qiu Clear advanced filters

  • Oncolytic viruses selectively kill tumour cells and induce anti-tumour immunity. Here, the AUs demonstrate the anti-viral effect of the mevalonate pathway on oncolytic virus M1 in refractory cancer cells and provide evidence for a combination strategy of targeting the mevalonate pathway for potentiating oncolytic virus therapy.

    • Jiankai Liang
    • Li Guo
    • Guangmei Yan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Oncolytic virotherapy is a promising strategy for cancer treatment. In this study, the authors demonstrate that DNA-dependent protein kinase (DNA-PK) inhibition sensitizes cancer cells to M1 virus and improves therapeutic effects in refractory cancer models in vivo and in patient tumour samples.

    • Xiao Xiao
    • Jiankai Liang
    • Guangmei Yan
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15