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Showing 1–2 of 2 results
Advanced filters: Author: Petar Marinković Clear advanced filters

  • Microtubule dynamics in neurons play critical roles in physiology, injury and disease. Here the authors develop a transgenic mouse line expressing a fluorescently tagged version of the microtubule binding protein EB3, and using a range of imaging techniques, study microtubule dynamics under normal and injury conditions in living mice.

    • Tatjana Kleele
    • Petar Marinković
    • Thomas Misgeld
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-10

  • Michael Breckwoldt and colleagues have developed a new approach to follow the mitochondrial redox potential of neurons with high spatio-temporal resolution. This multiparametric in vivo imaging approach is based on the transgenic expression of a biosensor for glutathione redox potential in neuronal mitochondria, with utility demonstrated in mouse models of amyotrophic lateral sclerosis and spinal cord injury. It should prove useful for studying mitochondrial pathology in neurological disease models.

    • Michael O Breckwoldt
    • Franz M J Pfister
    • Thomas Misgeld
    Research
    Nature Medicine
    Volume: 20, P: 555-560