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PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

Degradation of misfolded proteins from the endoplasmic reticulum (ER) is important for maintaining proper cellular protein homeostasis. Here, the authors discovered that the ER membrane protein PGRMC1 binds to misfolded prohormones for recruitment into the ER-phagy degradative pathway.

Yu-Jie Chen
Jeffrey Knupp
Billy Tsai
ResearchOpen Access13 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Regulated secretory cells go to the BAR for a bud

Syndromes caused by insufficient secretion of peptide hormones originate either from an inadequate population of endocrine secretory cells or from deficiencies in the secretory process. Two remarkable new studies highlight the importance of PICK1 and ICA69 in creating the protein storage organelles needed for regulated exocytosis, independent of stimulus-secretion coupling.

Peter Arvan
David Castle
News & Views25 Jun 2013
Nature Reviews Endocrinology

Volume: 9, P: 443-444
Restoration of PITPNA in Type 2 diabetic human islets reverses pancreatic beta-cell dysfunction

Type 2 diabetes (T2D) is characterized by pancreatic beta-cell failure. Here, the authors show restoration of Phosphatidylinositol transfer protein alpha (PITPNA), a mediator of PtdIns-4-phosphate synthesis in the trans-Golgi network, in human T2D islets reverses impaired insulin granule maturation, exocytosis, and ER stress.

Yu-Te Yeh
Chandan Sona
Matthew N. Poy
ResearchOpen Access17 Jul 2023
Nature Communications

Volume: 14, P: 1-19
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

Thyroid stimulating hormone (TSH) is critical for normal development and metabolism. Here, the authors conduct a GWAS and suggest protective effect of higher TSH on risk of thyroid cancer and goitre.

Wei Zhou
Ben Brumpton
Bjørn Olav Åsvold
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-13
Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogenesis

Chien-Wen Chen
Bo-Jhih Guan
Maria Hatzoglou
ResearchOpen Access08 Aug 2022
Nature Communications

Volume: 13, P: 1-18
Author Correction: GWAS of thyroid stimulating hormone highlights the pleiotropic effects and inverse association with thyroid cancer

Wei Zhou
Ben Brumpton
Bjørn Olav Åsvold
Amendments and CorrectionsOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1-2
Transgenic overexpression of microRNA-30d in pancreatic beta-cells progressively regulates beta-cell function and identity

Yiping Mao
Jacob Schoenborn
Xiaoqing Tang
ResearchOpen Access13 Jul 2022
Scientific Reports

Volume: 12, P: 1-12
Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway

Rita A. Avelar
Riya Gupta
Analisa DiFeo
ResearchOpen Access30 Sept 2024
Cell Death & Differentiation

Volume: 31, P: 1761-1775
Therapeutic opportunities for pancreatic β-cell ER stress in diabetes mellitus

This Review summarizes the mechanisms by which endoplasmic reticulum (ER) stress contributes to β-cell dysfunction and cell death in monogenic diabetes and type 2 diabetes mellitus (T2DM). In addition, the potential therapeutic strategies for T2DM and metabolic syndrome that target ER stress in β-cells are discussed.

Jing Yong
James D. Johnson
Randal J. Kaufman
Reviews23 Jun 2021
Nature Reviews Endocrinology

Volume: 17, P: 455-467
The role of thyroglobulin in thyroid hormonogenesis

T₃ and T₄ are synthesized in the thyroid gland in a process that involves the iodoglycoprotein thyroglobulin. In this Review, we consider the role of thyroglobulin in thyroid hormonogenesis from evolutionary, biochemical, molecular, cellular and physiological angles.

Cintia E. Citterio
Héctor M. Targovnik
Peter Arvan
Reviews18 Mar 2019
Nature Reviews Endocrinology

Volume: 15, P: 323-338
Improved in vivo imaging method for individual islets across the mouse pancreas reveals a heterogeneous insulin secretion response to glucose

Henriette Frikke-Schmidt
Peter Arvan
Corentin Cras-Méneur
ResearchOpen Access12 Jan 2021
Scientific Reports

Volume: 11, P: 1-15
Increased mitochondrial respiration promotes survival from endoplasmic reticulum stress

Jeffrey Knupp
Peter Arvan
Amy Chang
Research23 May 2018
Cell Death & Differentiation

Volume: 26, P: 487-501

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