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Showing 1–4 of 4 results
Advanced filters: Author: Peter B. Otoupal Clear advanced filters

  • Peter Otoupal et al. present CHAOS, an approach for preventing the development of antibiotic resistance in E. coli through CRISPR-Cas9-based perturbation of gene expression. They show that multiplexed perturbations decrease fitness of clinically-isolated Carbapenem-resistant E. coli upon antibiotic exposure.

    • Peter B. Otoupal
    • William T. Cordell
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 1, P: 1-13

  • Otoupal et al. use a systematic approach to investigate the effects of fitness neutral gene perturbations and antibiotic synergy in Escherichia coli. These neutral fitness interactions worked as co-therapies in a Salmonella enterica infection and informed the design of re-sensitization therapies in multi-drug resistant E. coli and Klebisiella pneumoniae clinical isolates.

    • Peter B. Otoupal
    • Kristen A. Eller
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-15

  • Bio-based production of oils and lipids could potentially provide a sustainable fuel alternative to petroleum. Here, the authors show that Yarrowia lipolytica’s metabolism can be rewired to saturate cells with upwards of 90% lipid content and significantly increase lipid production.

    • John Blazeck
    • Andrew Hill
    • Hal S. Alper
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Eller et al. develop a Facile Accelerated Specific Therapeutic (FAST) platform of antisense therapeutics that targets MDR bacterial pathogens with peptide nucleic acids (PNAs). This platform designs species and/or sequence specific PNAS based on a bioinformatics toolbox and offers a new delivery approach by repurposing the bacterial Type III secretion system in conjunction with a kill switch to overcome limited transport of PNAs into mammalian cells.

    • Kristen A. Eller
    • Thomas R. Aunins
    • Anushree Chatterjee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13