Myoclonus is characterized by sudden, involuntary jerks, and can be caused by a variety of acquired and genetic disorders. Identification of the aetiology of myoclonus is paramount, because treatment should be based on the underlying disorder. The authors propose a novel eight-step diagnostic algorithm for myoclonus, incorporating—for the first time—next-generation sequencing. The algorithm should aid clinical decision-making and facilitate mechanism-based treatment.
- Rodi Zutt
- Martje E. van Egmond
- Marina A. Tijssen