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Showing 1–9 of 9 results

Advanced filters: Author: Peter Espenshade Clear advanced filters

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones

Degradation of misfolded proteins from the endoplasmic reticulum (ER) is important for maintaining proper cellular protein homeostasis. Here, the authors discovered that the ER membrane protein PGRMC1 binds to misfolded prohormones for recruitment into the ER-phagy degradative pathway.

Yu-Jie Chen
Jeffrey Knupp
Billy Tsai
ResearchOpen Access13 Oct 2021
Nature Communications

Volume: 12, P: 1-17
Regulation and feedback of cholesterol metabolism

William Griffiths
Tom Freeman
Mathieu Blanc
ResearchOpen Access31 Aug 2011
Nature Precedings

P: 1
Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis

Fatty acids released by ATGL in adipose tissue inhibit post-translational activation of SREBP1c in the liver. We propose that this ATGL/SREBP-1c axis adds an additional layer of coordination between lipolysis and lipogenesis.

Paola Peña de la Sancha
Beatrix Irene Wieser
Paul Willibald Vesely
ResearchOpen Access09 Apr 2025
Communications Biology

Volume: 8, P: 1-14
Intracellular lipid surveillance by small G protein geranylgeranylation

In Caenorhabditis elegans, geranylgeranyl conjugation to RAB-11.1 acts as a lipid sensor to regulate nutrient uptake and lipid metabolism in response to metabolic demand.

Abigail Watterson
Lexus Tatge
Peter M. Douglas
Research18 May 2022
Nature

Volume: 605, P: 736-740
Dbl2 interacts with helicases and an endonuclease to maintain the integrity of repetitive regions

Anetta Bakosova
Lubos Cipak
Silvia Bagelova Polakova
ResearchOpen Access01 Jul 2025
Scientific Reports

Volume: 15, P: 1-18
Lighting the match: how a student-led career mentorship program can blaze the way for non-academic careers

Academic institutions can address the demand for multiskilled individuals who will be competitive in the non-academic job market by establishing a strong career mentorship program.

Anna Bagnell
Alana MacDonald
Mark Schenerman
Comments & Opinion15 Mar 2024
Nature Biotechnology

Volume: 42, P: 530-534
Sequential expression of the MAD family of transcriptional repressors during differentiation and development

Christophe Quéva
Peter J Hurlin
Robert N Eisenman
Research05 Mar 1998
Oncogene

Volume: 16, P: 967-977
Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition

Xin Gong
Jingxian Li
Nieng Yan
ResearchOpen Access13 Mar 2015
Cell Research

Volume: 25, P: 401-411
Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization

Xin Gong
Hongwu Qian
Nieng Yan
ResearchOpen Access04 Nov 2016
Cell Research

Volume: 26, P: 1197-1211