Nature Search

The network-based underpinnings of persisting symptoms after concussion: a multimodal neuroimaging meta-analysis

Persisting symptoms after concussion (PSaC) present a complex neuropsychiatric challenge with limited treatment options due to inconsistent neuroimaging findings. Here the authors employ a multi-analytic approach to identify the salience network as a core dysfunction hub in PSaC, proposing specific cortical regions as potential targets for personalized neuromodulation therapies.

Adriano Mollica
Robin F. H. Cash
Sean M. Nestor
ResearchOpen Access23 Sept 2025
Nature Mental Health

Volume: 3, P: 1276-1290
A MYC and RAS co-activation signature in localized prostate cancer drives bone metastasis and castration resistance

Using lineage tracing and molecular profiling, Abate-Shen and colleagues identify a Ras and Myc co-activation signature that predicts metastasis and castration resistance in localized prostate cancer.

Juan M. Arriaga
Sukanya Panja
Cory Abate-Shen
Research19 Oct 2020
Nature Cancer

Volume: 1, P: 1082-1096
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Antidepressant drugs are the most common treatment for depressive episodes but only a fraction of patients experience adequate response. Here the authors find dysregulation of miRNAs in peripheral blood samples from depressed patients after antidepressant treatment, and show that the miRNAs are regulators of psychiatrically relevant signalling pathways.

Juan Pablo Lopez
Laura M. Fiori
Gustavo Turecki
ResearchOpen Access22 May 2017
Nature Communications

Volume: 8, P: 1-12
Resting-State Cortico-Thalamic-Striatal Connectivity Predicts Response to Dorsomedial Prefrontal rTMS in Major Depressive Disorder

Tim V Salomons
Katharine Dunlop
Jonathan Downar
ResearchOpen Access13 Sept 2013
Neuropsychopharmacology

Volume: 39, P: 488-498
Reductions in Cortico-Striatal Hyperconnectivity Accompany Successful Treatment of Obsessive-Compulsive Disorder with Dorsomedial Prefrontal rTMS

Katharine Dunlop
Blake Woodside
Jonathan Downar
ResearchOpen Access06 Oct 2015
Neuropsychopharmacology

Volume: 41, P: 1395-1403
EEG Power Asymmetry and Functional Connectivity as a Marker of Treatment Effectiveness in DBS Surgery for Depression

Maher A Quraan
Andrea B Protzner
Mary P McAndrews
Research28 Nov 2013
Neuropsychopharmacology

Volume: 39, P: 1270-1281
Cognitive effects of focal neuromodulation in neurological and psychiatric disorders

Focal neuromodulation approaches are promising therapeutic options for challenging-to-treat neurological and psychiatric symptoms, but might indirectly or directly affect cognition. In this Review, Rabin et al. describe the cognitive effects of transcranial magnetic stimulation, deep brain stimulation and ablative techniques.

Micaela Wiseman
Isabella J. Sewell
Jennifer S. Rabin
Reviews14 Mar 2024
Nature Reviews Psychology

Volume: 3, P: 242-260
Large-scale structural network change correlates with clinical response to rTMS in depression

Sean M. Nestor
Arsalan Mir-Moghtadaei
Jonathan Downar
Research02 Feb 2022
Neuropsychopharmacology

Volume: 47, P: 1096-1105
Examining cognitive change in magnetic resonance-guided focused ultrasound capsulotomy for psychiatric illness

Benjamin Davidson
Clement Hamani
Jennifer S. Rabin
ResearchOpen Access11 Nov 2020
Translational Psychiatry

Volume: 10, P: 1-10
Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants

Chelsey Ju
Laura M. Fiori
Gustavo Turecki
ResearchOpen Access08 Oct 2019
Translational Psychiatry

Volume: 9, P: 1-12
Deep brain stimulation of the nucleus accumbens in the treatment of severe alcohol use disorder: a phase I pilot trial

Benjamin Davidson
Peter Giacobbe
Nir Lipsman
Research21 Jul 2022
Molecular Psychiatry

Volume: 27, P: 3992-4000
Magnetic resonance-guided focused ultrasound capsulotomy for refractory obsessive compulsive disorder and major depressive disorder: clinical and imaging results from two phase I trials

Benjamin Davidson
Clement Hamani
Nir Lipsman
Research14 May 2020
Molecular Psychiatry

Volume: 25, P: 1946-1957

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