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Showing 1–2 of 2 results
Advanced filters: Author: Peter Haertsch Clear advanced filters

  • Epithelial tissue mononuclear phagocytes (MNP) can transmit HIV to CD4 T cells, but less is known about sub-epithelial cells. Here, the authors describe MNPs in human anogenital and colorectal tissues and find that CD14+CD1c+ monocyte-derived dendritic cells and langerin-expressing conventional dendritic cells 2 preferentially take up and transmit HIV.

    • Jake W. Rhodes
    • Rachel A. Botting
    • Andrew N. Harman
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Composition and function of immune populations at barrier surfaces is crucial for response to infection. Here, the authors identify a population of dendritic cells in human epidermis, abundant in anogenital epithelia and distinct from Langerhans cells by surface phenotype and by high capacity for HIV infection and transmission.

    • Kirstie M. Bertram
    • Rachel A. Botting
    • Andrew N. Harman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15