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Showing 1–16 of 16 results
Advanced filters: Author: Peter J Goadsby Clear advanced filters

  • Migraine is a common disabling brain disorder that—considering its clinical and economic impact—is understudied and in need of additional management options. In this Review, Peter Goadsby outlines new pharmaceutical and device-based approaches to migraine treatment by describing their potential mechanisms of action and the clinical data that are currently available.

    • Peter J Goadsby
    Reviews
    Nature Clinical Practice Neurology
    Volume: 3, P: 610-619

  • Training in different countries and societies can provide important insights into the sociocultural factors that influence the perception and management of disease. In this article, Michele Viana compares and contrasts his experiences of training at headache centers in Italy and the USA, highlighting differences in attitudes towards headache and its treatment between these two countries.

    • Michele Viana
    Comments & Opinion
    Nature Reviews Neurology
    Volume: 7, P: 710-712

  • Premonitory symptoms of migraine can start hours to days before the onset of headache. In this Review, Karsan and Goadsby discuss the phenotypes of these premonitory symptoms and the insights that they provide into the neurobiology of migraine.

    • Nazia Karsan
    • Peter J. Goadsby
    Reviews
    Nature Reviews Neurology
    Volume: 14, P: 699-710

  • The trigeminal nerve has a key role in migraine. An atlas of cell types and gene-expression profiles for cells in this nerve in mice and humans promises to improve our understanding of head pain.

    • Philip R. Holland
    • Peter J. Goadsby
    News & Views
    Nature
    Volume: 607, P: 39-40

  • Chronic migraine is a severely disabling condition that is poorly recognized and undertreated by clinicians. Much debate has existed over the nomenclature and diagnostic criteria for this condition and, until 2007, there had been a paucity of clinical trial data for preventive therapies. In this Review, Diener and colleagues discuss the evolution of terminology and definitions used for chronic migraine, as well as the epidemiology, pathophysiology and treatment of this condition.

    • Hans-Christoph Diener
    • David W. Dodick
    • Stephen D. Silberstein
    Reviews
    Nature Reviews Neurology
    Volume: 8, P: 162-171

  • Over the past 300 years, the migraine field has been dominated by two theories—the vascular theory and the central neuronal theory. The vascular theory was bolstered by the finding that vasoconstrictors are effective in acute migraine treatment, but evidence is now emerging that vasodilatation is neither necessary nor sufficient to trigger a migraine attack. Ho et al. consider the evidence pointing towards a neuronal mechanism in migraine development, highlighting the role of calcitonin gene-related peptide and its receptors.

    • Tony W. Ho
    • Lars Edvinsson
    • Peter J. Goadsby
    Reviews
    Nature Reviews Neurology
    Volume: 6, P: 573-582

  • The occurrence of subarachnoid hemorrhage (SAH) in patients with acute headache is strongly associated with the presence of several clinical variables. Nevertheless, the absence of such variables should not discourage physicians from investigating for SAH in individuals with headache peaking in intensity within a few minutes of onset.

    • Farooq H. Maniyar
    • Peter J. Goadsby
    News & Views
    Nature Reviews Neurology
    Volume: 7, P: 134-135

  • In the past 10 years, the realization that migraine is a brain disorder rather than a vascular disorder has facilitated development of various treatments, ranging from innovative immunopharmaceuticals through to neurostimulation. Many clinical trials have been successful, and such considerable progress holds promise for the coming decade of migraine treatment.

    • Peter J. Goadsby
    News & Views
    Nature Reviews Neurology
    Volume: 11, P: 621-622

  • In this Review, Wei and Goadsby discuss the pathophysiology of cluster headache, the treatments available and their mechanisms, and the insights being provided by results from trials of emerging treatments, which indicate mechanistic differences between episodic and chronic cluster headache.

    • Diana Y. Wei
    • Peter J. Goadsby
    Reviews
    Nature Reviews Neurology
    Volume: 17, P: 308-324

  • Migraine is a complex and disabling brain disorder that is currently difficult to prevent or treat. Goadsby and colleagues review the evidence that regions of the brainstem and forebrain are involved in modulating migraine pain and that dysfunction in these areas may contribute to the pathophysiology of the disorder.

    • Simon Akerman
    • Philip R. Holland
    • Peter J. Goadsby
    Reviews
    Nature Reviews Neuroscience
    Volume: 12, P: 570-584

  • Migraine is a common headache disorder. This Primer by Ferrari and colleagues summarizes the epidemiology, pathophysiology, diagnosis and treatment of migraine. Moreover, quality of life issues faced by patients with migraine and future research avenues are discussed.

    • Michel D. Ferrari
    • Peter J. Goadsby
    • David W. Dodick
    Reviews
    Nature Reviews Disease Primers
    Volume: 8, P: 1-20