Nature Search

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

Saloner et al. used large-scale cerebrospinal fluid proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression.

Rowan Saloner
Adam M. Staffaroni
Kaitlin B. Casaletto
ResearchOpen Access16 May 2025
Nature Aging

Volume: 5, P: 1143-1158
The social contingency of momentary subjective well-being

Comparing oneself to others is inherently human but exactly how social comparison affects one's emotional state is unclear. Here the authors demonstrate that unequal social outcomes decrease happiness and these emotional impacts are proportional to individual levels of generosity.

Robb B. Rutledge
Archy O. de Berker
Raymond J. Dolan
ResearchOpen Access13 Jun 2016
Nature Communications

Volume: 7, P: 1-8
Dopamine Increases a Value-Independent Gambling Propensity

Francesco Rigoli
Robb B Rutledge
Raymond J Dolan
ResearchOpen Access06 May 2016
Neuropsychopharmacology

Volume: 41, P: 2658-2667
The Subjective Lowering of Pitch

E. C. SHERWOOD
Research04 Jul 1901
Nature

Volume: 64, P: 233
The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions

Jacek Lubkowski
Grzegorz Bujacz
Wlodawer Alexander
Research01 Jan 1997
Nature Structural Biology

Volume: 4, P: 64-69
A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation

Two fMRI studies (n = 358) show that cognitive regulation of negative emotion alters cortical activity but not amygdala or other subcortical areas. Regulation-related activity overlaps with emotion generation systems but also involves distinct areas.

Ke Bo
Thomas E. Kraynak
Tor D. Wager
Research22 Mar 2024
Nature Neuroscience

Volume: 27, P: 975-987
The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

Nicolai I. Burzlaff
Peter J. Rutledge
Jack E. Baldwin
Research14 Oct 1999
Nature

Volume: 401, P: 721-724
Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid

Prarthana Devi
Sarah M. Barry
Peter J. Rutledge
ResearchOpen Access08 May 2015
Scientific Reports

Volume: 5, P: 1-6
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

New antimalarials are urgently needed. Here, the authors identify Open Source Malaria compound, OSMS-106, as a reaction hijacking inhibitor of the malaria parasite protein synthesis machinery, with potential use for treatment and prophylaxis.

Stanley C. Xie
Yinuo Wang
Leann Tilley
ResearchOpen Access31 Jan 2024
Nature Communications

Volume: 15, P: 1-18
Comprehensive genomic characterization of squamous cell lung cancers

Comprehensive analyses of 178 lung squamous cell carcinomas by The Cancer Genome Atlas project show that the tumour type is characterized by complex genomic alterations, with statistically recurrent mutations in 11 genes, including TP53 in nearly all samples; a potential therapeutic target is identified in most of the samples studied.

Peter S. Hammerman
Michael S. Lawrence
Matthew Meyerson
ResearchOpen Access09 Sept 2012
Nature

Volume: 489, P: 519-525
New RAB3GAP1 mutations in patients with Warburg Micro Syndrome from different ethnic backgrounds and a possible founder effect in the Danish

Deborah J Morris-Rosendahl
Reeval Segel
Fran Faes
Research26 May 2010
European Journal of Human Genetics

Volume: 18, P: 1100-1106
Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

Heather J. Lacey
Rachel Chen
Andrew M. Piggott
ResearchOpen Access26 Jul 2022
The Journal of Antibiotics

Volume: 75, P: 483-490
Insights into the accuracy of social scientists’ forecasts of societal change

How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists’ forecasts were on average no more accurate than those of simple statistical models.

Igor Grossmann
Amanda Rotella
Tom Wilkening
Research09 Feb 2023
Nature Human Behaviour

Volume: 7, P: 484-501
Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Microorganisms produce a wealth of structurally diverse specialized metabolites with great potential for use in medicine and agriculture. In this Review, Rutledge and Challis provide an overview of the approaches that are available to identify and activate cryptic microbial biosynthetic gene clusters, which represent an untapped reservoir of useful metabolites.

Peter J. Rutledge
Gregory L. Challis
Reviews29 Jun 2015
Nature Reviews Microbiology

Volume: 13, P: 509-523
Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, with subgroup analyses suggesting that the antibody profile in donor plasma is critical in determining clinical outcomes.

Philippe Bégin
Jeannie Callum
Donald M. Arnold
ResearchOpen Access09 Sept 2021
Nature Medicine

Volume: 27, P: 2012-2024
Symbiosis in chemistry and biology

What do organic synthesis, mechanistic enzymology, structural biology and glycoscience have in common? They all span chemistry and biology, benefit from and contribute to multidisciplinary approaches, and were up for discussion at a recent symposium in Dublin.

Paul V Murphy
Peter J Rutledge
News & Views01 Feb 2006
Nature Chemical Biology

Volume: 2, P: 59-62
Moral transgressions corrupt neural representations of value

Crockett et al. used model-based fMRI to investigate the neural basis of decisions to profit from harming others vs. themselves. Most people preferred to harm themselves over others for profit. This moral preference was associated with diminished neural responses in value-sensitive brain regions to profit gained from harming others.

Molly J Crockett
Jenifer Z Siegel
Raymond J Dolan
Research01 May 2017
Nature Neuroscience

Volume: 20, P: 879-885
Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study

Peter P. Nghiem
Alexis M. Rutledge
Nicolaas E. P. Deutz
ResearchOpen Access02 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Yeppoonic acids A – D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp.

Heather Lacey
Rachel Chen
Andrew M. Piggott
Research09 Dec 2021
The Journal of Antibiotics

Volume: 75, P: 108-112
Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Research10 Jan 2022
Nature Medicine

Volume: 28, P: 53-58
Neurocomputational mechanisms underpinning aberrant social learning in young adults with low self-esteem

Geert-Jan Will
Michael Moutoussis
Raymond J. Dolan
ResearchOpen Access17 Mar 2020
Translational Psychiatry

Volume: 10, P: 1-14
A relatively common homozygous TRAPPC4 splicing variant is associated with an early-infantile neurodegenerative syndrome

Shereen G. Ghosh
Marcello Scala
Joseph G. Gleeson
Research08 Sept 2020
European Journal of Human Genetics

Volume: 29, P: 271-279
Conglobatins B–E: cytotoxic analogues of the C₂-symmetric macrodiolide conglobatin

Heather J. Lacey
Thomas J. Booth
Andrew M. Piggott
Research17 Jun 2020
The Journal of Antibiotics

Volume: 73, P: 756-765
Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Magdalena Koczkowska
Tom Callens
Ludwine M. Messiaen
ResearchOpen Access07 Sept 2018
Genetics in Medicine

Volume: 21, P: 867-876
Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Philippe Bégin
Jeannie Callum
Donald M. Arnold
Amendments and CorrectionsOpen Access12 Jan 2022
Nature Medicine

Volume: 28, P: 212
Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

Diana H. Quan
Gayathri Nagalingam
James A. Triccas
ResearchOpen Access07 Oct 2019
Scientific Reports

Volume: 9, P: 1-10
Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Magdalena Koczkowska
Tom Callens
Ludwine M. Messiaen
Amendments and Corrections02 Oct 2018
Genetics in Medicine

Volume: 21, P: 764-765

Search

Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration

The social contingency of momentary subjective well-being

Dopamine Increases a Value-Independent Gambling Propensity

The Subjective Lowering of Pitch

The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions

A systems identification approach using Bayes factors to deconstruct the brain bases of emotion regulation

The reaction cycle of isopenicillin N synthase observed by X-ray diffraction

Synthesis and structural characterisation of amides from picolinic acid and pyridine-2,6-dicarboxylic acid

Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase

Comprehensive genomic characterization of squamous cell lung cancers

New RAB3GAP1 mutations in patients with Warburg Micro Syndrome from different ethnic backgrounds and a possible founder effect in the Danish

Suertides A–C: selective antibacterial cyclic hexapeptides from Amycolatopsis sp. MST-135876v3

Insights into the accuracy of social scientists’ forecasts of societal change

Discovery of microbial natural products by activation of silent biosynthetic gene clusters

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Symbiosis in chemistry and biology

Moral transgressions corrupt neural representations of value

Beta-hydroxy-beta-methylbutyrate (HMB) improves daily activity and whole-body protein metabolism in Duchenne muscular dystrophy dogs: a pilot study

Yeppoonic acids A – D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp.

Reply to: Concerns about estimating relative risk of death associated with convalescent plasma for COVID-19

Neurocomputational mechanisms underpinning aberrant social learning in young adults with low self-esteem

A relatively common homozygous TRAPPC4 splicing variant is associated with an early-infantile neurodegenerative syndrome

Conglobatins B–E: cytotoxic analogues of the C₂-symmetric macrodiolide conglobatin

Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

Author Correction: Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Bengamides display potent activity against drug-resistant Mycobacterium tuberculosis

Correction: Expanding the clinical phenotype of individuals with a 3-bp in-frame deletion of the NF1 gene (c.2970_2972del): an update of genotype–phenotype correlation

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