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Showing 1–6 of 6 results

Advanced filters: Author: Peter Kühnen Clear advanced filters

Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity

A mutation leading to ubiquitous ectopic expression of agouti signaling protein, which is not picked up in conventional genetic screenings, is reported in patients with severe childhood obesity.

Elena Kempf
Kathrin Landgraf
Antje Körner
ResearchOpen Access19 Dec 2022
Nature Metabolism

Volume: 4, P: 1697-1712
An ontology-based rare disease common data model harmonising international registries, FHIR, and Phenopackets

Adam S. L. Graefe
Miriam R. Hübner
Sylvia Thun
ResearchOpen Access08 Feb 2025
Scientific Data

Volume: 12, P: 1-22
Spatiotemporal expression of thyroid hormone transporter MCT8 and THRA mRNA in human cerebral organoids recapitulating first trimester cortex development

Adina Sophie Graffunder
Audrey Amber Julie Bresser
Robert Opitz
ResearchOpen Access23 Apr 2024
Scientific Reports

Volume: 14, P: 1-16
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Treatment with setmelanotide, a new-generation MC4R agonist, provides durable weight loss in hyperphagic, leptin receptor–deficient patients, suggesting a pharmacological avenue to treat patients with various MC4R pathway defects.

Karine Clément
Heike Biebermann
Peter Kühnen
Research07 May 2018
Nature Medicine

Volume: 24, P: 551-555
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide

Nicolas A. Heyder
Gunnar Kleinau
Patrick Scheerer
ResearchOpen Access24 Sept 2021
Cell Research

Volume: 31, P: 1176-1189
Interactions between nocturnal melatonin secretion, metabolism, and sleeping behavior in adolescents with obesity

Johanna Overberg
Laura Kalveram
Susanna Wiegand
ResearchOpen Access09 Feb 2022
International Journal of Obesity

Volume: 46, P: 1051-1058