Nature Search

Seasonal hydrochemical characteristics of spring water in Southern Poland: integrating geochemical modeling, health risk analysis and mitigation strategies

Mohamed Hamdy Eid
Omar Saeed
Vahid Nourani
ResearchOpen Access15 Jul 2025
Scientific Reports

Volume: 15, P: 1-27
Understanding the genetic complexity of puberty timing across the allele frequency spectrum

A multi-ancestry genome-wide association study for age at menarche followed by fine mapping and downstream analysis implicates 665 pubertal timing genes, such as the G-protein-coupled receptor 83 (GPR83) and other genes expressed in the ovaries involved in the DNA damage response.

Katherine A. Kentistou
Lena R. Kaisinger
Ken K. Ong
ResearchOpen Access01 Jul 2024
Nature Genetics

Volume: 56, P: 1397-1411
Genetic insights into biological mechanisms governing human ovarian ageing

Hundreds of genetic loci associated with age at menopause, combined with experimental evidence in mice, highlight mechanisms of reproductive ageing across the lifespan.

Katherine S. Ruth
Felix R. Day
John R. B. Perry
Research04 Aug 2021
Nature

Volume: 596, P: 393-397
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

John Perry, Ken Ong and colleagues analyze genotype data on ∼370,000 women and identify 389 independent signals that associate with age at menarche, implicating ∼250 genes. Their analyses suggest causal inverse associations, independent of BMI, between puberty timing and risks for breast and endometrial cancers in women and prostate cancer in men.

Felix R Day
Deborah J Thompson
John R B Perry
Research24 Apr 2017
Nature Genetics

Volume: 49, P: 834-841
The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

The authors report how the cold and heat sensing properties of the pain receptor TRPA1 are separately modulated by the C-terminal intracellular domain, and in concert with either the S1–S4 or the S5–S6 transmembrane domain.

Lavanya Moparthi
Viktor Sinica
Peter M. Zygmunt
ResearchOpen Access17 Oct 2022
Nature Communications

Volume: 13, P: 1-15
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

John Perry and colleagues report the results of a large genome-wide association study meta-analysis to identify variants influencing age at natural menopause. They identify 54 independent signals and find enrichment near genes involved in delayed puberty and DNA damage response.

Felix R Day
Katherine S Ruth
Anna Murray
Research28 Sept 2015
Nature Genetics

Volume: 47, P: 1294-1303
Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

TRPV2 is activated by temperature and cannabinoids. Here, the authors have used cryo-EM and electrophysiology to identify a cannabinoid binding site distinct from that of cannabidiol as a possible drug target for treatment of inflammation and immune-mediated diseases.

Liying Zhang
Charlotte Simonsen
Peter M. Zygmunt
ResearchOpen Access05 Dec 2022
Nature Communications

Volume: 13, P: 1-18
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Kathryn Lunetta and colleagues report a meta-analysis of 22 genome-wide association studies for age at menopause. They identify 13 loci newly associated with age at natural menopause, including several candidate genes with roles in DNA repair and immune function.

Lisette Stolk
John R B Perry
Kathryn L Lunetta
Research22 Jan 2012
Nature Genetics

Volume: 44, P: 260-268
H₂S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Nitric oxide (NO) and hydrogen sulphide (H₂S) are two gaseous signalling molecules produced in tissues. Here the authors propose that NO and H₂S react with each other to form nitroxyl (HNO), which activates the TRPA1 channel in nerve cells and triggers the release of the vasoactive peptide CGRP.

Mirjam Eberhardt
Maria Dux
Milos R. Filipovic
ResearchOpen Access15 Jul 2014
Nature Communications

Volume: 5, P: 1-17
Global trait–environment relationships of plant communities

Although plant functional trait combinations reflect ecological trade-offs at the species level, little is known about how this translates to whole communities. Here, the authors show that global trait composition is captured by two main dimensions that are only weakly related to macro-environmental drivers.

Helge Bruelheide
Jürgen Dengler
Ute Jandt
Research19 Nov 2018
Nature Ecology & Evolution

Volume: 2, P: 1906-1917
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

Peter M. Zygmunt
Jesper Petersson
Edward D. Högestätt
Research29 Jul 1999
Nature

Volume: 400, P: 452-457
A TR(i)P in the air

Monitoring oxygen (O₂) levels is essential to optimizing aerobic metabolism and ensuring proper biological processes in most eukaryotes. The spice chemosensor TRPA1 is a previously unidentified O₂ sensor in the mammalian sensory nervous system that warns against hyperoxia and hypoxia.

Peter M Zygmunt
News & Views19 Sept 2011
Nature Chemical Biology

Volume: 7, P: 661-663
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Sven-Eric Jordt
Diana M. Bautista
David Julius
Research07 Jan 2004
Nature

Volume: 427, P: 260-265
Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase

Yunyi Wei
Juan Antonio Contreras
Zygmunt S. Derewenda
Research01 Apr 1999
Nature Structural Biology

Volume: 6, P: 340-345
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

Here 106 genomic loci associated with age at menarche, a marker of puberty timing in females, are identified; these loci show enrichment for genes involved in nuclear hormone receptor function, body mass index, and rare disorders of puberty, and for genes located in imprinted regions, with parent-of-origin specific effects at several loci.

John R. B. Perry
Felix Day
Ken K. Ong
Research23 Jul 2014
Nature

Volume: 514, P: 92-97
TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ⁹-tetrahydrocannabiorcol

TRPA1 is a key ion channel in pain signalling. This study shows that activation of TRPA1 in the spinal cord by acetaminophen metabolites and a non-electrophilic cannabinoid produces antinociception that is lost in mice lacking TRPA1, providing an explanation for the analgesic activity of acetaminophen.

David A Andersson
Clive Gentry
Peter M Zygmunt
Research22 Nov 2011
Nature Communications

Volume: 2, P: 1-11
Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Katherine A. Kentistou
Lena R. Kaisinger
Ken K. Ong
Amendments and CorrectionsOpen Access09 Jul 2024
Nature Genetics

Volume: 56, P: 1763-1764
Rare coding variants and X-linked loci associated with age at menarche

Previous studies have linked over 100 genomic loci to age-at-menarche but that work was restricted to common autosomal variation. Here, Lunetta et al. identify associations with rare protein-coding and X-linked variants, implicating new mechanisms that regulate puberty timing.

Kathryn L. Lunetta
Felix R. Day
John R. B. Perry
ResearchOpen Access04 Aug 2015
Nature Communications

Volume: 6, P: 1-8
Expansion of B4GALT7 linkeropathy phenotype to include perinatal lethal skeletal dysplasia

Theresa Mihalic Mosher
Deborah A. Zygmunt
Kim L. McBride
Research05 Jul 2019
European Journal of Human Genetics

Volume: 27, P: 1569-1577
TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

TRPA1 has been reported to contribute lung cancer adenocarcinoma (LUAD), but the mechanisms are unclear. Here the authors propose that TRPA1/FGFR2 interaction is functional in LUAD and show that astrocytes oppose brain metastasis by mediating the downregulation of TRPA1 through exosome-delivered miRNA-142-3p.

Jonathan Berrout
Eleni Kyriakopoulou
Zahra Timsah
ResearchOpen Access16 Oct 2017
Nature Communications

Volume: 8, P: 1-15
TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

Lauri J. Moilanen
Mirka Laavola
Eeva Moilanen
ResearchOpen Access24 Apr 2012
Scientific Reports

Volume: 2, P: 1-6
Lactate is a potent inhibitor of the capsaicin receptor TRPV1

Jeanne de la Roche
Isabella Walther
Andreas Leffler
ResearchOpen Access09 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

Lavanya Moparthi
Tatjana I. Kichko
Peter M. Zygmunt
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Discrepancies in reporting the CAG repeat lengths for Huntington's disease

Oliver W Quarrell
Olivia Handley
G Bernhard Landwehrmeyer
Research03 Aug 2011
European Journal of Human Genetics

Volume: 20, P: 20-26

Search

Seasonal hydrochemical characteristics of spring water in Southern Poland: integrating geochemical modeling, health risk analysis and mitigation strategies

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Genetic insights into biological mechanisms governing human ovarian ageing

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk

The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

H₂S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Global trait–environment relationships of plant communities

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

A TR(i)P in the air

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

Crystal structure of brefeldin A esterase, a bacterial homolog of the mammalian hormone-sensitive lipase

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche

TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ⁹-tetrahydrocannabiorcol

Publisher Correction: Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Rare coding variants and X-linked loci associated with age at menarche

Expansion of B4GALT7 linkeropathy phenotype to include perinatal lethal skeletal dysplasia

TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

TRPA1 Contributes to the Acute Inflammatory Response and Mediates Carrageenan-Induced Paw Edema in the Mouse

Lactate is a potent inhibitor of the capsaicin receptor TRPV1

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

Discrepancies in reporting the CAG repeat lengths for Huntington's disease

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