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Showing 1–11 of 11 results
Advanced filters: Author: Peter M. Haverty Clear advanced filters

  • Complete genome sequencing has already provided insights into the mutation spectra of several cancer types. Here, the first complete sequences are provided of a primary lung tumour and adjacent normal tissue. Comparison of the two reveals a variety of somatic mutations in the cancer genome, including changes in the KRAS proto-oncogene. The results reveal a distinct pattern of selection against mutations within expressed genes compared to non-expressed genes, and selection against mutations in promoter regions.

    • William Lee
    • Zhaoshi Jiang
    • Zemin Zhang
    Research
    Nature
    Volume: 465, P: 473-477

  • The genetic basis of gastric cancer, the fourth most common cancer worldwide, remains poorly understood. Here, the authors sequence and analyse the exomes and transcriptomes of primary gastric tumours and cell lines, and identify a ZAK kinase isoform that may have an oncogenic role in gastric cancer.

    • Jinfeng Liu
    • Mark McCleland
    • Zemin Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-8

  • Large-scale analyses of the drug sensitivity of cancer cell lines have been previously reported to yield conflicting conclusions; this Analysis uses independently generated data to demonstrate that consistency can be achieved if key laboratory and data analysis practices are considered when future studies are undertaken.

    • Peter M. Haverty
    • Eva Lin
    • Richard Bourgon
    Research
    Nature
    Volume: 533, P: 333-337

  • Somasekar Seshagiri, James Brugarolas and colleagues report the mutational landscape of 167 non–clear cell renal cell carcinomas (nccRCCs) from multiple subtypes. They identify subtype-specific driver mutations and gene fusions, including ones involving MITF, which result in expression of the anti-apoptotic protein BIRC7 and might thus indicate candidates for treatment with BIRC7 inhibitors.

    • Steffen Durinck
    • Eric W Stawiski
    • Somasekar Seshagiri
    Research
    Nature Genetics
    Volume: 47, P: 13-21

  • Exomes, transcriptomes and copy-number alterations in a sample of more than 70 primary human colonic tumours were analysed in an attempt to characterize the genomic landscape; in addition to finding alterations in genes associated with commonly mutated signalling pathways, recurrent gene fusions involving R-spondin family members were also found to occur in approximately 10% of colonic tumours, revealing a potential new therapeutic target.

    • Somasekar Seshagiri
    • Eric W. Stawiski
    • Frederic J. de Sauvage
    ResearchOpen Access
    Nature
    Volume: 488, P: 660-664

  • These authors performed a large-scale study in which they identified 2,576 somatic mutations across 1,507 coding genes from 441 breast, lung, ovarian and prostate cancer types and subtypes. The study provides an overview of the mutational spectra across major human cancers, implies an expanded role for Gα subunits in multiple cancer types and identifies several potential therapeutic targets.

    • Zhengyan Kan
    • Bijay S. Jaiswal
    • Somasekar Seshagiri
    Research
    Nature
    Volume: 466, P: 869-873

  • A comprehensive analysis of RNA sequencing and single-nucleotide polymorphism (SNP) array data provides new insights into the biology of 675 human cancer cell lines

    • Christiaan Klijn
    • Steffen Durinck
    • Zemin Zhang
    Research
    Nature Biotechnology
    Volume: 33, P: 306-312