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Showing 1–6 of 6 results
Advanced filters: Author: Peter Refsing Andersen Clear advanced filters

  • How the nuclear exosome is targeted to nuclear RNA substrates is poorly understood. An affinity-capture MS approach and functional analyses now demonstrate a physical and functional connection between the human exosome and the cap-binding complex (CBC). A CBC-containing complex was found to promote transcription termination of several RNA types, thus suggesting a direct link to exosomal RNA degradation.

    • Peter Refsing Andersen
    • Michal Domanski
    • Torben Heick Jensen
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1367-1376

  • Despite our growing understanding of their complexity, different types of RNA are still classified using technical rather than functional criteria. Andersson et al.show that categorization of RNAs based on stability and direction of transcription is an effective means of functional classification.

    • Robin Andersson
    • Peter Refsing Andersen
    • Albin Sandelin
    Research
    Nature Communications
    Volume: 5, P: 1-10

  • Transcription of Drosophila PIWI-interacting RNA (piRNA) clusters is enforced through RNA polymerase II pre-initiation complex formation within repressive heterochromatin, accomplished through the transcription factor IIA subunit paralogue Moonshiner.

    • Peter Refsing Andersen
    • Laszlo Tirian
    • Julius Brennecke
    Research
    Nature
    Volume: 549, P: 54-59

  • The nature of small RNA species derived from gene termini and intron-exon junctions is now further examined. By sequencing transcripts between 12 and 100 nucleotides derived from cells depleted for RNA decay factors as well as those associated with Argonaute proteins, insights into how these RNAs are produced is provided. Moreover, new small RNAs are identified.

    • Eivind Valen
    • Pascal Preker
    • Torben Heick Jensen
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 1075-1082

  • Using the FANTOM5 CAGE expression atlas, the authors show that bidirectional capped RNAs are a signature feature of active enhancers and identify over 40,000 enhancer candidates from over 800 human cell and tissue samples across the whole human body.

    • Robin Andersson
    • Claudia Gebhard
    • Albin Sandelin
    Research
    Nature
    Volume: 507, P: 455-461

  • The nuclear cap–binding complex (CBC) stimulates RNA maturation, but the mechanistic basis is not well understood. In vitro reconstitution experiments combined with functional analyses have revealed a new CBC complex containing ARS2, a major effector of CBC. ARS2 links the cap to 3'-end maturation for several RNA families, thus favoring the production of short RNAs.

    • Marie Hallais
    • Frédéric Pontvianne
    • Edouard Bertrand
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1358-1366