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Remodelling of the active presequence translocase drives motor-dependent mitochondrial protein translocation

The ATPase activity of the chaperone Hsp70 drives protein translocation across the mitochondrial membrane. Schulz and Rehling show that continuous recruitment and dissociation of the Hsp70 ATPase activator Pam18 is required to regulate the activity of the import motor.

Christian Schulz
Peter Rehling
Research10 Jul 2014
Nature Communications

Volume: 5, P: 1-9
Integrating mitochondrial translation into the cellular context

Recent findings revealed the extent to which mitochondrial translation and other cellular processes are mutually controlled. Mitochondrial translation is coordinated with the assembly of respiratory chain complexes and is positively regulated by microRNAs imported from the cytoplasm. In turn, mitochondrial translation stress activates retrograde signalling pathways that suppress cell proliferation.

Ricarda Richter-Dennerlein
Sven Dennerlein
Peter Rehling
Reviews16 Sept 2015
Nature Reviews Molecular Cell Biology

Volume: 16, P: 586-592
Super-resolution microscopy of mitochondrial mRNAs

Stoldt, Maass, and colleagues present a study where smFISH is combined with STED and MINFLUX microscopy to map mitochondrial mRNA at nanometre resolution, enabling the exploration of the structural folding and distribution of mRNAs within mitochondria.

Stefan Stoldt
Frederike Maass
Stefan Jakobs
ResearchOpen Access10 Jul 2025
Nature Communications

Volume: 16, P: 1-11
Inventory control: cytochrome c oxidase assembly regulates mitochondrial translation

Respiratory chain subunits are made up of proteins encoded by nuclear and mitochondrial DNA, which assemble to form functional enzymes. New findings reveal that the mitochondrial translation of Cox1, the core component of cytochromecoxidase, is directly coupled to the assembly of this respiratory complex.

David U. Mick
Thomas D. Fox
Peter Rehling
Reviews22 Dec 2010
Nature Reviews Molecular Cell Biology

Volume: 12, P: 14-20
Guarding the gate for mitochondrial entry

The protein-import systems of organelles can become clogged by proteins. A protein from one organelle, the endoplasmic reticulum, is found to also unclog such blockages in mitochondrial organelles.

Sylvie Callegari
Peter Rehling
News & Views22 May 2019
Nature

Volume: 569, P: 635-637
Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver

Dysfunctions of the mitochondrial OXPHOS system lead to severe human disorders. Here, the authors analyzed a mouse mutant that mimics a mitochondrial disorder patient and find that reactive oxygen species trigger RNA release and inflammatory pathway in liver.

Abhishek Aich
Angela Boshnakovska
Peter Rehling
ResearchOpen Access12 Aug 2024
Nature Communications

Volume: 15, P: 1-20
Tinkering with nature

Describes the identification and structural characterization of the Sec61 translocase.

Peter Rehling
Research Highlights08 Jun 2011
Nature Reviews Molecular Cell Biology

Volume: 12, P: 401
Coupling of ribosome biogenesis and translation initiation in human mitochondria

Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis and a potential coupling to translation initiation.

Marleen Heinrichs
Anna Franziska Finke
Ricarda Richter-Dennerlein
ResearchOpen Access17 Apr 2025
Nature Communications

Volume: 16, P: 1-16
An avoidance segment resolves a lethal nuclear–mitochondrial targeting conflict during ribosome assembly

Oborská-Oplová et al. report a conserved mitochondrial avoidance segment in the cytosolic ribosomal protein uS5 that prevents mistargeting of uS5 to the mitochondrial matrix and ensures cytosolic ribosomal assembly.

Michaela Oborská-Oplová
Alexander Gregor Geiger
Vikram Govind Panse
Research31 Jan 2025
Nature Cell Biology

Volume: 27, P: 336-346
Mapping protein interactions in the active TOM-TIM23 supercomplex

The TOM and TIM23 complexes facilitate the transport of nuclear-encoded proteins into the mitochondrial matrix. Here, the authors use a stalled client protein to purify the translocation supercomplex and gain insight into the TOM-TIM23 interface and the mechanism of protein handover from the TOM to the TIM23 complex.

Ridhima Gomkale
Andreas Linden
Peter Rehling
ResearchOpen Access29 Sept 2021
Nature Communications

Volume: 12, P: 1-17
Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer.

Alexander Benjamin Schendzielorz
Piotr Bragoszewski
Peter Rehling
ResearchOpen Access02 Oct 2018
Nature Communications

Volume: 9, P: 1-10
Pam16 has an essential role in the mitochondrial protein import motor

Ann E Frazier
Jan Dudek
Peter Rehling
Research15 Feb 2004
Nature Structural & Molecular Biology

Volume: 11, P: 226-233
Formation of AP-3 transport intermediates requires Vps41 function

Peter Rehling
Tamara Darsow
Scott D. Emr
Research09 Sept 1999
Nature Cell Biology

Volume: 1, P: 346-353
INA complex liaises the F₁F_o-ATP synthase membrane motor modules

The inner membrane assembly complex (INAC) interacts with components of the F₁F₀-ATP synthase but its function remains unclear. Here the authors show that INAC associates with two distinct complexes during F₁F₀-ATP synthase formation, which points towards a safeguarding role during proton-conducting channel assembly.

Nataliia Naumenko
Marcel Morgenstern
Peter Rehling
ResearchOpen Access01 Nov 2017
Nature Communications

Volume: 8, P: 1-14
Motor-free mitochondrial presequence translocase drives membrane integration of preproteins

Martin van der Laan
Michael Meinecke
Peter Rehling
Research09 Sept 2007
Nature Cell Biology

Volume: 9, P: 1152-1159
A roadmap for ribosome assembly in human mitochondria

Lavdovskaia, Hanitsch, Linden et al. provide a comprehensive roadmap of mitoribosome biogenesis and establish that mitochondria use a unique pathway for the assembly of their translation machinery.

Elena Lavdovskaia
Elisa Hanitsch
Ricarda Richter-Dennerlein
ResearchOpen Access11 Jul 2024
Nature Structural & Molecular Biology

Volume: 31, P: 1898-1908
IDH3γ functions as a redox switch regulating mitochondrial energy metabolism and contractility in the heart

Protein targets that are affected by ROS and underly impaired inotropic effects in the heart are largely unknown. Here, the authors identify the γ-subunit of IDH3 as a redox switch linking oxidative stress to impaired metabolism and heart function.

Maithily S. Nanadikar
Ana M. Vergel Leon
Dörthe M. Katschinski
ResearchOpen Access14 Apr 2023
Nature Communications

Volume: 14, P: 1-19
Mitochondrial import and the twin-pore translocase

Peter Rehling
Katrin Brandner
Nikolaus Pfanner
Reviews01 Jul 2004
Nature Reviews Molecular Cell Biology

Volume: 5, P: 519-530
Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy

Studies on interferon-driven brain pathology have so far been hampered by the lack of appropriate animal models. Here the authors characterize RNASET2-deficient mice and show that neuroinflammation and brain atrophy are IFNAR1-dependent.

Matthias Kettwig
Katharina Ternka
Jutta Gärtner
ResearchOpen Access11 Nov 2021
Nature Communications

Volume: 12, P: 1-18
Rounding of low serum creatinine levels and consequent impact on accuracy of bedside estimates of renal function in cancer patients

M J Dooley
S Singh
D Rischin
ResearchOpen Access02 Mar 2004
British Journal of Cancer

Volume: 90, P: 991-995
Precisely measured protein lifetimes in the mouse brain reveal differences across tissues and subcellular fractions

Measuring precise protein turnover rates in animals is technically challenging at the proteomic level. Here, Fornasiero and colleagues use isotopic labeling with mass spectrometry and mathematical modeling to accurately determine protein lifetimes in the mouse brain

Eugenio F. Fornasiero
Sunit Mandad
Silvio O. Rizzoli
ResearchOpen Access12 Oct 2018
Nature Communications

Volume: 9, P: 1-17
White pupae phenotype of tephritids is caused by parallel mutations of a MFS transporter

The white pupae (wp) phenotype has been used for decades to selectively remove females of tephritid species in genetic sexing, but the determining gene is unknown. Here, the authors show that wp phenotype is produced by parallel mutations in a Major Facilitator Superfamily domain containing gene across multiple species.

Christopher M. Ward
Roswitha A. Aumann
Marc F. Schetelig
ResearchOpen Access21 Jan 2021
Nature Communications

Volume: 12, P: 1-12
RNF40 epigenetically modulates glycolysis to support the aggressiveness of basal-like breast cancer

Evangelos Prokakis
Shaishavi Jansari
Florian Wegwitz
ResearchOpen Access28 Sept 2023
Cell Death & Disease

Volume: 14, P: 1-17
The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain

Sunit Mandad
Raza-Ur Rahman
Eugenio F. Fornasiero
ResearchOpen Access15 Nov 2018
Scientific Reports

Volume: 8, P: 1-19

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