Nature Search

Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

Furlanis, Traunmüller et al. uncover hundreds of alternative splicing events that distinguish neuronal cell classes. Splice isoforms primarily encode synaptic and intrinsic neuronal properties. Data are available online in the SpliceCode database.

Elisabetta Furlanis
Lisa Traunmüller
Peter Scheiffele
Research26 Aug 2019
Nature Neuroscience

Volume: 22, P: 1709-1717
Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling

Signalling by the developmental morphogen BMP2 through the transcription factor SMAD1 has a key role in controlling the glutamatergic innervation of parvalbumin-expressing interneurons and maintaining the balance between excitation and inhibition in the mammalian cortex.

Zeynep Okur
Nadia Schlauri
Peter Scheiffele
ResearchOpen Access17 Apr 2024
Nature

Volume: 629, P: 402-409
Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

Daniel Bernard, Jan Wit, Mehul Dattani, Krishna Chatterjee and colleagues show that mutations in IGSF1 cause a new X-linked syndrome characterized by central hypothyroidism and testicular enlargement. Their findings implicate IGSF1 as a positive regulator of thyrotropin-releasing hormone signaling in the anterior pituitary.

Yu Sun
Beata Bak
Daniel J Bernard
Research11 Nov 2012
Nature Genetics

Volume: 44, P: 1375-1381
Rescue of oxytocin response and social behaviour in a mouse model of autism

An autism-associated mutation in Nlgn3 results in impaired oxytocin signalling in dopaminergic neurons and altered social behavioural responses in mice, and treatment with an inhibitor of MAP kinase-interacting kinases rescues these phenotypes.

Hanna Hörnberg
Enrique Pérez-Garci
Peter Scheiffele
Research05 Aug 2020
Nature

Volume: 584, P: 252-256
Regulation of striatal cells and goal-directed behavior by cerebellar outputs

Cerebellar outputs contribute to motor as well as cognitive behaviors. Here, the authors elucidate the connectivity between deep cerebellar nuclei and specific cell types in the striatum via the intralaminar thalamic nucleus and the participation of this circuit in striatum-dependent behavior.

Le Xiao
Caroline Bornmann
Peter Scheiffele
ResearchOpen Access07 Aug 2018
Nature Communications

Volume: 9, P: 1-14
Correction: Corrigendum: Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

Kensuke Futai
Myung Jong Kim
Yasunori Hayashi
Amendments and Corrections01 Feb 2008
Nature Neuroscience

Volume: 11, P: 238
Angelman syndrome connections

Neuronal networks in the brain that develop early in life underlie our ability to learn, remember and communicate. Genetic defects that perturb the fine-tuning of such neuronal connectivity can cause disease.

Peter Scheiffele
Asim A. Beg
News & Views15 Dec 2010
Nature

Volume: 468, P: 907-908
Sculpting neuronal connectivity

It emerges that a transcription program differentially regulates inhibitory inputs in distinct neuronal compartments — an unexpected coordinated switch for achieving experience-dependent 'plasticity' in neural circuits. See Letter p.121

Emily Sylwestrak
Peter Scheiffele
News & Views06 Nov 2013
Nature

Volume: 503, P: 42-43
N-glycans as apical sorting signals in epithelial cells

Peter Scheiffele
Johan Peränen
Kai Simons
Research02 Nov 1995
Nature

Volume: 378, P: 96-98
Neurexins: molecular codes for shaping neuronal synapses

The molecular basis of trans-synaptic signalling by Neurexins plays an important role in synapse organization. In this Review, Scheiffele and colleagues link cell type-specific alternative splicing to the combinatorial action of Neurexin isoforms, and provide a mechanistic framework for Neurexin functions in synapse organization.

Andrea M. Gomez
Lisa Traunmüller
Peter Scheiffele
Reviews08 Jan 2021
Nature Reviews Neuroscience

Volume: 22, P: 137-151
Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

Kensuke Futai
Myung Jong Kim
Yasunori Hayashi
Research21 Jan 2007
Nature Neuroscience

Volume: 10, P: 186-195
Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Synaptic assembly depends on trans-synaptic Neurexin/Neuroligin signalling. Here, Muhammad et al. show that Spinophilin, a pre-synaptic scaffolding protein, interacts with Neurexin, in competition with Syd-1, to regulate the formation and function of synaptic active zones at Drosophilaneuromuscular junctions.

Karzan Muhammad
Suneel Reddy-Alla
Stephan J. Sigrist
ResearchOpen Access16 Oct 2015
Nature Communications

Volume: 6, P: 1-15
Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Individuals with autism spectrum disorder have alteration in social and novelty behaviors. Here, Bellone and colleagues show that chemogenetic inhibition of mouse dopamine neurons in the ventral tegmental area can blunt exploration towards unfamiliar conspecifics, and that these behavioral deficits are recapitulated in mice lacking neuroligin3 gene product.

Sebastiano Bariselli
Hanna Hörnberg
Camilla Bellone
ResearchOpen Access09 Aug 2018
Nature Communications

Volume: 9, P: 1-15
Neurexin mediates the assembly of presynaptic terminals

Camin Dean
Francisco G Scholl
Peter Scheiffele
Research08 Jun 2003
Nature Neuroscience

Volume: 6, P: 708-716
Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

This study shows that Epac2, a cAMP-activated Rap-GEF, acts downstream of D1/D5 dopamine receptor signaling to regulate dendritic spines and synaptic transmission. The authors also show that rare mutations of the EPAC2 gene that are associated with autism cause defects in Epac2-mediated spine remodeling.

Kevin M Woolfrey
Deepak P Srivastava
Peter Penzes
Research06 Sept 2009
Nature Neuroscience

Volume: 12, P: 1275-1284
Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure

Yoko Iijima
Katharina Behr
Peter Scheiffele
ResearchOpen Access06 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

Jianwen Liu
Joanne M Lewohl
R Dayne Mayfield
Research02 Nov 2005
Neuropsychopharmacology

Volume: 31, P: 1574-1582
Mixed-culture assays for analyzing neuronal synapse formation

Thomas Biederer
Peter Scheiffele
Protocols29 Mar 2007
Nature Protocols

Volume: 2, P: 670-676
LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling

Evan Vickers
Denys Osypenko
Ralf Schneggenburger
ResearchOpen Access22 Jun 2020
Scientific Reports

Volume: 10, P: 1-12

Search

Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

Control of neuronal excitation–inhibition balance by BMP–SMAD1 signalling

Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement

Rescue of oxytocin response and social behaviour in a mouse model of autism

Regulation of striatal cells and goal-directed behavior by cerebellar outputs

Correction: Corrigendum: Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

Angelman syndrome connections

Sculpting neuronal connectivity

N-glycans as apical sorting signals in epithelial cells

Neurexins: molecular codes for shaping neuronal synapses

Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95–neuroligin

Presynaptic spinophilin tunes neurexin signalling to control active zone architecture and function

Role of VTA dopamine neurons and neuroligin 3 in sociability traits related to nonfamiliar conspecific interaction

Neurexin mediates the assembly of presynaptic terminals

Epac2 induces synapse remodeling and depression and its disease-associated forms alter spines

Distinct Defects in Synaptic Differentiation of Neocortical Neurons in Response to Prenatal Valproate Exposure

Patterns of Gene Expression in the Frontal Cortex Discriminate Alcoholic from Nonalcoholic Individuals

Mixed-culture assays for analyzing neuronal synapse formation

LTP of inhibition at PV interneuron output synapses requires developmental BMP signaling

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