Nature Search

The timing of crustal extension and the eruption of continental flood basalts

Peter R. Hooper
Research17 May 1990
Nature

Volume: 345, P: 246-249
Correction: Corrigendum: Methylglyoxal modification of Na_v1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

Angelika Bierhaus
Thomas Fleming
Peter P Nawroth
Amendments and Corrections07 Sept 2012
Nature Medicine

Volume: 18, P: 1445
Phenotyping sensory nerve endings in vitro in the mouse

Katharina Zimmermann
Alexander Hein
Peter W Reeh
Protocols22 Jan 2009
Nature Protocols

Volume: 4, P: 174-196
H₂S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Nitric oxide (NO) and hydrogen sulphide (H₂S) are two gaseous signalling molecules produced in tissues. Here the authors propose that NO and H₂S react with each other to form nitroxyl (HNO), which activates the TRPA1 channel in nerve cells and triggers the release of the vasoactive peptide CGRP.

Mirjam Eberhardt
Maria Dux
Milos R. Filipovic
ResearchOpen Access15 Jul 2014
Nature Communications

Volume: 5, P: 1-17
Methylglyoxal modification of Na_v1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

Glucose and its metabolic derivatives are increased the plasma of patients with diabetes. Peter Nawroth and colleagues demonstrate that one such metabolite, methylglyoxal, is increased in patients with painful diabetic neuropathy, and find that it acts by modifying the excitability characteristics of a sodium channel protein.

Angelika Bierhaus
Thomas Fleming
Peter P Nawroth
Research13 May 2012
Nature Medicine

Volume: 18, P: 926-933
Sensory neuron sodium channel Na_v1.8 is essential for pain at low temperatures

Sensory acuity deteriorates at cold temperatures, but pain perception persists and cold stimuli themselves can be painful. A voltage-gated sodium channel, Na_v1.8, is implicated in this perception. Unlike other channels, Na_v1.8 does not inactivate at lower temperatures and its currents are actually larger in colder conditions

Katharina Zimmermann
Andreas Leffler
Peter W. Reeh
Research14 Jun 2007
Nature

Volume: 447, P: 856-859
Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

Boyd and LoCoco et al. link ω-6 polyunsaturated fatty acid–rich diet to development of peripheral nerve damage in mice, revealing diet as a risk factor for chronic pain.

Jacob T. Boyd
Peter M. LoCoco
Kenneth M. Hargreaves
Research17 Jun 2021
Nature Metabolism

Volume: 3, P: 762-773
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

Nitin Agarwal
Pal Pacher
Rohini Kuner
Research10 Jun 2007
Nature Neuroscience

Volume: 10, P: 870-879
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Gram-negative bacterial infections can often cause inflammation and pain. Meseguer et al. show that the inflammation and pain result from the direct activation of nociceptor TRPA1 channels by lipopolysaccharide, a major component of the outer membrane of Gram-negative bacteria.

Victor Meseguer
Yeranddy A. Alpizar
Félix Viana
ResearchOpen Access20 Jan 2014
Nature Communications

Volume: 5, P: 1-14
Lactate is a potent inhibitor of the capsaicin receptor TRPV1

Jeanne de la Roche
Isabella Walther
Andreas Leffler
ResearchOpen Access09 Nov 2016
Scientific Reports

Volume: 6, P: 1-13
Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

Lavanya Moparthi
Tatjana I. Kichko
Peter M. Zygmunt
ResearchOpen Access28 Jun 2016
Scientific Reports

Volume: 6, P: 1-10
Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates

Katharina Reeh
Peter A. Summers
Ramon Vilar
ResearchOpen Access28 Oct 2020
Scientific Reports

Volume: 10, P: 1-10
Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

Beatrice Oehler
Katrin Kistner
Heike L. Rittner
ResearchOpen Access14 Jul 2017
Scientific Reports

Volume: 7, P: 1-22
Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

Katrin Kistner
Norbert Siklosi
Matthias A. Engel
ResearchOpen Access30 Jun 2016
Scientific Reports

Volume: 6, P: 1-11
A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation

Katharina S. Appel
Chin Huang Lee
Jörg Janne Vehreschild
ResearchOpen Access13 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Complementary roles of murine Na_V1.7, Na_V1.8 and Na_V1.9 in acute itch signalling

Helen Kühn
Leonie Kappes
Andreas E. Kremer
ResearchOpen Access11 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients

Carolin E. M. Koll
Sina M. Hopff
O. Witzke
ResearchOpen Access21 Dec 2022
Scientific Data

Volume: 9, P: 1-15

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The timing of crustal extension and the eruption of continental flood basalts

Correction: Corrigendum: Methylglyoxal modification of Na_v1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

Phenotyping sensory nerve endings in vitro in the mouse

H₂S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

Methylglyoxal modification of Na_v1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

Sensory neuron sodium channel Na_v1.8 is essential for pain at low temperatures

Elevated dietary ω-6 polyunsaturated fatty acids induce reversible peripheral nerve dysfunction that exacerbates comorbid pain conditions

Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins

Lactate is a potent inhibitor of the capsaicin receptor TRPV1

Human TRPA1 is a heat sensor displaying intrinsic U-shaped thermosensitivity

Design, synthesis and evaluation of a tripodal receptor for phosphatidylinositol phosphates

Inflammatory pain control by blocking oxidized phospholipid-mediated TRP channel activation

Systemic desensitization through TRPA1 channels by capsazepine and mustard oil - a novel strategy against inflammation and pain

A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation

Complementary roles of murine Na_V1.7, Na_V1.8 and Na_V1.9 in acute itch signalling

Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients

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