Nature Search

Mapping human visual cortex with positron emission tomography

Peter T. Fox
Mark A. Mintun
David C. Van Essen
Research30 Oct 1986
Nature

Volume: 323, P: 806-809
Next-generation in vivo optical imaging with short-wave infrared quantum dots

Functionalized InAs quantum dots emitting in the short-wavelength infrared spectral region enable functional biomedical imaging at unprecedentedly high spatial resolution, deep penetration and fast acquisition speeds.

Oliver T. Bruns
Thomas S. Bischof
Moungi G. Bawendi
Research10 Apr 2017
Nature Biomedical Engineering

Volume: 1, P: 1-11
Mechanotransduction through growth-factor shedding into the extracellular space

Daniel J. Tschumperlin
Guohao Dai
Jeffrey M. Drazen
Research21 Apr 2004
Nature

Volume: 429, P: 83-86
Novel genetic loci associated with hippocampal volume

The hippocampus in mammalian brain varies in size across individuals. Here, Hibar and colleagues perform a genome-wide association meta-analysis to find six genetic loci with significant association to hippocampus volume.

Derrek P. Hibar
Hieab H. H. Adams
M. Arfan Ikram
ResearchOpen Access18 Jan 2017
Nature Communications

Volume: 8, P: 1-12
ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

Basal-like breast cancer is a heterogeneous disease with poor prognosis; however, its cellular origins and aetiology are poorly understood. Here the authors provide evidence that ID4 is a key controller of mammary stem/progenitor cell self-renewal, acting upstream of Notch signalling to repress luminal fate commitment.

Simon Junankar
Laura A. Baker
Alexander Swarbrick
Research27 Mar 2015
Nature Communications

Volume: 6, P: 1-12
Control of coherent information via on-chip photonic–phononic emitter–receivers

Integrated photonics hold potential for signal processing but some operations are difficult to perform in all-optical devices. Here, Shin et al. use the coupling between coherent photons and phonons in nanophotonic waveguides to demonstrate frequency-selective, narrow-linewidth radiofrequency photonic filters.

Heedeuk Shin
Jonathan A. Cox
Peter T. Rakich
ResearchOpen Access05 Mar 2015
Nature Communications

Volume: 6, P: 1-8
On-chip inter-modal Brillouin scattering

Here, Kittlauset al. demonstrate stimulated inter-modal Brillouin scattering on-chip. Through this process, a Brillouin interaction couples light fields that propagate in distinct spatial modes of a Brillouin-active silicon waveguide, which may allow a variety of new processes in silicon photonics.

Eric A. Kittlaus
Nils T. Otterstrom
Peter T. Rakich
ResearchOpen Access07 Jul 2017
Nature Communications

Volume: 8, P: 1-9
Novel genetic loci underlying human intracranial volume identified through genome-wide association

In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

Hieab H H Adams
Derrek P Hibar
Paul M Thompson
Research03 Oct 2016
Nature Neuroscience

Volume: 19, P: 1569-1582
MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

BH3-only protein tBID induces mitochondrial outer membrane permeabilization in response to death receptor activation. The mitochondrial carrier homologue 2 (MTCH2) protein acts as the tBID receptor on the mitochondria and is required for fas-induced cell death in mouse liver.

Yehudit Zaltsman
Liat Shachnai
Atan Gross
Research02 May 2010
Nature Cell Biology

Volume: 12, P: 553-562
Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide and genetic susceptibility to the disease is poorly understood. Here, the authors combine data from Japanese, African American and European samples and identify a common variant in VTI1Athat increases CRC risk across all populations.

Hansong Wang
Terrilea Burnett
Loïc Le Marchand
Research08 Aug 2014
Nature Communications

Volume: 5, P: 1-7
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Scholsburg and colleagues show that prolonged inactivation of monoacylglycerol lipase, the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol, antagonizes the brain endocannabinoid system. This is manifested as tolerance, impaired plasticity and receptor desensitization; these effects are similar to the effects of prolonged exposure to drugs of abuse.

Joel E Schlosburg
Jacqueline L Blankman
Benjamin F Cravatt
Research22 Aug 2010
Nature Neuroscience

Volume: 13, P: 1113-1119
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Barbara Franke
Jason L Stein
Patrick F Sullivan
Research01 Feb 2016
Nature Neuroscience

Volume: 19, P: 420-431
Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner

Aram Prokop
Wolf Wrasidlo
Peter T Daniel
Research11 Dec 2003
Oncogene

Volume: 22, P: 9107-9120
The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

Silke Radetzki
Claus-Henning Köhne
Peter T Daniel
Research24 Jan 2002
Oncogene

Volume: 21, P: 227-238
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

A fraction of the intestinal microbiota as precise as a single bacterial species confers infection resistance by synthesizing Clostridium difficile-inhibiting metabolites from host-derived bile salts.

Charlie G. Buffie
Vanni Bucci
Eric G. Pamer
Research22 Oct 2014
Nature

Volume: 517, P: 205-208
Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik

Malte Oppermann
Christoph C Geilen
Jürgen Eberle
Research04 Jul 2005
Oncogene

Volume: 24, P: 7369-7380
Common genetic variants influence human subcortical brain structures

Genome-wide association studies are used to identify common genetic variants that affect the structure of selected subcortical regions of the human brain; their identification provides insight into the causes of variability in brain development and may help to determine mechanisms of neuropsychiatric dysfunction.

Derrek P. Hibar
Jason L. Stein
Sarah E. Medland
Research21 Jan 2015
Nature

Volume: 520, P: 224-229
Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

Carl Anderson and colleagues report dense genotyping, using the Immunochip array, of 2,861 primary biliary cirrhosis (PBC) cases and 8,514 controls. They identify three loci newly associated with PBC, and their fine-mapping of previous susceptibility loci identifies five regions with multiple independent common, low-frequency and rare variant associations.

Jimmy Z Liu
Mohamed A Almarri
Carl A Anderson
Research09 Sept 2012
Nature Genetics

Volume: 44, P: 1137-1141
Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

Clarissa von Haefen
Thomas Wieder
Peter T Daniel
Research17 Apr 2003
Oncogene

Volume: 22, P: 2236-2247
Adenovirus-mediated overexpression of p14^ARF induces p53 and Bax-independent apoptosis

Philipp G Hemmati
Bernhard Gillissen
Peter T Daniel
Research07 May 2002
Oncogene

Volume: 21, P: 3149-3161
Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway

Christian Scholz
Antje Richter
Peter T Daniel
Research11 Jul 2005
Oncogene

Volume: 24, P: 7031-7042
Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

Katrin Friedrich
Thomas Wieder
Peter T Daniel
Research17 May 2001
Oncogene

Volume: 20, P: 2749-2760
TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway

Jana Wendt
Clarissa von Haefen
Peter T Daniel
Research04 Apr 2005
Oncogene

Volume: 24, P: 4052-4064
Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB

Karin Schmelz
Thomas Wieder
Peter-T Daniel
Research26 Jul 2004
Oncogene

Volume: 23, P: 6743-6759
CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants

Jürgen Eberle
Lothar F Fecker
Christoph C Geilen
Research11 Dec 2003
Oncogene

Volume: 22, P: 9131-9141
An improved prognostic model for stage T1a and T1b prostate cancer by assessments of cancer extent

Ramzi Rajab
Gabrielle Fisher
Daniel M Berney
Research10 Sept 2010
Modern Pathology

Volume: 24, P: 58-63
Loss of p21 disrupts p14^ARF-induced G1 cell cycle arrest but augments p14^ARF-induced apoptosis in human carcinoma cells

Philipp G Hemmati
Guillaume Normand
Peter T Daniel
Research07 Mar 2005
Oncogene

Volume: 24, P: 4114-4128
Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway

Clarissa von Haefen
Bernhard Gillissen
Peter T Daniel
Research27 Sept 2004
Oncogene

Volume: 23, P: 8320-8332
Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway

Christian Scholz
Thomas Wieder
Peter T Daniel
Research24 Jan 2005
Oncogene

Volume: 24, P: 1904-1913
Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

Clarissa von Haefen
Thomas Wieder
Peter T Daniel
Research05 Jun 2002
Oncogene

Volume: 21, P: 4009-4019
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway

Antje Klöpfer
Anne Hasenjäger
Peter T Daniel
Research01 Nov 2004
Oncogene

Volume: 23, P: 9408-9418
The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x_L protein

Mandar R Bhonde
Marie-Luise Hanski
Christoph Hanski
Research27 Sept 2004
Oncogene

Volume: 24, P: 148-156
Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x_L in a strictly caspase-3-dependent manner in human carcinoma cells

Anne Hasenjäger
Bernhard Gillissen
Peter T Daniel
Research05 Apr 2004
Oncogene

Volume: 23, P: 4523-4535
Type I and type II reactions in TRAIL-induced apoptosis – results from dose–response studies

Justine Rudner
Verena Jendrossek
Claus Belka
Research08 Nov 2004
Oncogene

Volume: 24, P: 130-140

Search

Mapping human visual cortex with positron emission tomography

Next-generation in vivo optical imaging with short-wave infrared quantum dots

Mechanotransduction through growth-factor shedding into the extracellular space

Novel genetic loci associated with hippocampal volume

ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype

Control of coherent information via on-chip photonic–phononic emitter–receivers

On-chip inter-modal Brillouin scattering

Novel genetic loci underlying human intracranial volume identified through genome-wide association

MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria

Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept

Induction of apoptosis by enediyne antibiotic calicheamicin ϑII proceeds through a caspase-mediated mitochondrial amplification loop in an entirely Bax-dependent manner

The apoptosis promoting Bcl-2 homologues Bak and Nbk/Bik overcome drug resistance in Mdr-1-negative and Mdr-1-overexpressing breast cancer cell lines

Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile

Caspase-independent induction of apoptosis in human melanoma cells by the proapoptotic Bcl-2-related protein Nbk / Bik

Common genetic variants influence human subcortical brain structures

Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis

Paclitaxel-induced apoptosis in BJAB cells proceeds via a death receptor-independent, caspases-3/-8-driven mitochondrial amplification loop

Adenovirus-mediated overexpression of p14^ARF induces p53 and Bax-independent apoptosis

Arsenic trioxide induces regulated, death receptor-independent cell death through a Bcl-2-controlled pathway

Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance

TRAIL sensitizes for ionizing irradiation-induced apoptosis through an entirely Bax-dependent mitochondrial cell death pathway

Tumor necrosis factor α sensitizes malignant cells to chemotherapeutic drugs via the mitochondrial apoptosis pathway independently of caspase-8 and NF-κB

CD95/Fas signaling in human melanoma cells: conditional expression of CD95L/FasL overcomes the intrinsic apoptosis resistance of malignant melanoma and inhibits growth and progression of human melanoma xenotransplants

An improved prognostic model for stage T1a and T1b prostate cancer by assessments of cancer extent

Loss of p21 disrupts p14^ARF-induced G1 cell cycle arrest but augments p14^ARF-induced apoptosis in human carcinoma cells

Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway

Arsenic trioxide triggers a regulated form of caspase-independent necrotic cell death via the mitochondrial death pathway

Ceramide induces mitochondrial activation and apoptosis via a Bax-dependent pathway in human carcinoma cells

Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the mitochondrial cell death pathway

The broad-range cyclin-dependent kinase inhibitor UCN-01 induces apoptosis in colon carcinoma cells through transcriptional suppression of the Bcl-x_L protein

Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x_L in a strictly caspase-3-dependent manner in human carcinoma cells

Type I and type II reactions in TRAIL-induced apoptosis – results from dose–response studies

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