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Showing 1–9 of 9 results

Advanced filters: Author: Peyton B. Randolph Clear advanced filters

Author Correction: Engineered pegRNAs improve prime editing efficiency

James W. Nelson
Peyton B. Randolph
David R. Liu
Amendments and Corrections08 Dec 2021
Nature Biotechnology

Volume: 40, P: 432
Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen
Mengjia Hong
Dali Li
Amendments and Corrections24 Apr 2024
Nature Biotechnology

Volume: 42, P: 987
Engineered pegRNAs improve prime editing efficiency

Stabilizing pegRNAs with 3′ RNA structures increases prime editing efficiency.

James W. Nelson
Peyton B. Randolph
David R. Liu
Research04 Oct 2021
Nature Biotechnology

Volume: 40, P: 402-410
Continuous evolution of SpCas9 variants compatible with non-G PAMs

PAM sequences without G bases can be edited with SpCas9 variants that were continuously evolved in the laboratory.

Shannon M. Miller
Tina Wang
David R. Liu
Research10 Feb 2020
Nature Biotechnology

Volume: 38, P: 471-481
A prime editor mouse to model a broad spectrum of somatic mutations in vivo

Prime-editing mouse models enable the study of specific cancer mutations in vivo.

Zackery A. Ely
Nicolas Mathey-Andrews
Tyler Jacks
Research11 May 2023
Nature Biotechnology

Volume: 42, P: 424-436
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

A base editor for precise adenine transversions is demonstrated in mouse embryos.

Liang Chen
Mengjia Hong
Dali Li
Research15 Jun 2023
Nature Biotechnology

Volume: 42, P: 638-650
Efficient prime editing in mouse brain, liver and heart with dual AAVs

Prime editors are efficiently delivered to mouse organs with AAV vectors.

Jessie R. Davis
Samagya Banskota
David R. Liu
ResearchOpen Access04 May 2023
Nature Biotechnology

Volume: 42, P: 253-264
Search-and-replace genome editing without double-strand breaks or donor DNA

A new DNA-editing technique called prime editing offers improved versatility and efficiency with reduced byproducts compared with existing techniques, and shows potential for correcting disease-associated mutations.

Andrew V. Anzalone
Peyton B. Randolph
David R. Liu
Research21 Oct 2019
Nature

Volume: 576, P: 149-157
Designing and executing prime editing experiments in mammalian cells

This protocol describes prime editing (PE) and twinPE experiments as well as the design and optimization of pegRNAs. The authors provide guidelines for selecting the proper PE system for a given application and how to perform PE in mammalian cells.

Jordan L. Doman
Alexander A. Sousa
David R. Liu
Protocols08 Aug 2022
Nature Protocols

Volume: 17, P: 2431-2468