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Showing 1–4 of 4 results
Advanced filters: Author: Phil G. Dinning Clear advanced filters

  • This Consensus Statement provides a conceptual and methodological framework to expand research on colonic motility in experimental animals and humans. The work is intended to facilitate the development of new drugs for common colonic motility disorders and of appropriate diagnostic and therapeutic algorithms for the management of paediatric and adult patients.

    • Maura Corsetti
    • Marcello Costa
    • Jan Tack
    ReviewsOpen Access
    Nature Reviews Gastroenterology & Hepatology
    Volume: 16, P: 559-579

  • Defaecation is a coordinated process that requires a morphologically intact gastrointestinal tract and the integration of multiple physiological systems (neuromuscular, hormonal and cognitive). This Review describes the physiology of human defaecation and continence, providing insights into the pathophysiology of defaecation and evacuation disorders.

    • Paul T. Heitmann
    • Paul F. Vollebregt
    • S. Mark Scott
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 18, P: 751-769

  • Constipation describes a variety of symptoms, including hard stools, excessive straining, infrequent bowel movements, bloating and abdominal pain. This Primer by Camilleri et al. describes the epidemiology, mechanisms, diagnosis and management of primary chronic constipation in adults.

    • Michael Camilleri
    • Alexander C. Ford
    • Lin Chang
    Reviews
    Nature Reviews Disease Primers
    Volume: 3, P: 1-19

  • Nick Spencer et al. made simultaneous multi-site electrophysiological recordings with video imaging of colonic wall movements from ex vivo mouse colon, in order to correlate propulsion of content with underlying electrical signals from the smooth muscle. Their results demonstrate that excitatory and inhibitory junction potentials are synchronized in both the proximal and distal colon, suggesting that the enteric nervous system network communicates over a longer range than previously expected.

    • Nick J. Spencer
    • Lee Travis
    • Julian Sorensen
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-17