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Showing 1–18 of 18 results
Advanced filters: Author: Philip C. Bevilacqua Clear advanced filters

  • RNA compartmentalization is essential for cellular functions and may have played a pivotal role in the emergence of life. However, the consequences of compartmentalization on RNA catalysis have been largely unexplored. Here, partitioning of catalytic RNA in a two-phase aqueous polymer solution increased local RNA concentration, enhancing ribozyme kinetics.

    • Christopher A. Strulson
    • Rosalynn C. Molden
    • Philip C. Bevilacqua
    Research
    Nature Chemistry
    Volume: 4, P: 941-946

  • Bioreactors need to separate the internal environment from the bulk, while also allowing entry and exit of substrate and product. Here, the authors make highly uniform, semipermeable droplets using an aqueous two-phase system, and show potential as microreactors based on a ribozyme cleavage reaction.

    • Daniel C. Dewey
    • Christopher A. Strulson
    • Christine D. Keating
    Research
    Nature Communications
    Volume: 5, P: 1-9

  • The concentration of divalent cations is well-known to influence molecular processes such as enzymatic activity and RNA folding. Here the authors attempt to reproduce physiological conditions for RNA folding in vitro and establish an important contribution of chelated magnesium ions in enhancing RNA function.

    • Ryota Yamagami
    • Jamie L. Bingaman
    • Philip C. Bevilacqua
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Short cationic peptides and nucleotides can form complex coacervates, but the influence of reduced multivalency on coacervate functionality was not investigated. Here, the authors report that coacervates formed from short polyions generate distinct pH microenvironments, accumulate RNA and preserve nucleic acid duplexes more efficiently than their longer counterparts.

    • Fatma Pir Cakmak
    • Saehyun Choi
    • Christine D. Keating
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Membraneless compartments have been theorized to be prebiotic micro-compartments as they spontaneously encapsulate RNA and proteins. Here, the authors report membraneless compartments can enhance RNA chemistries, affecting template directed RNA polymerization and stimulating nucleic acid enzymes.

    • Raghav R. Poudyal
    • Rebecca M. Guth-Metzler
    • Philip C. Bevilacqua
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Experimental work and computational modeling together reveal a suite of catalytic roles of the GlcN6P cofactor in the glmS ribozyme, including activation of the nucleophile, electrostatic stabilization, and alignment of the active site.

    • Jamie L Bingaman
    • Sixue Zhang
    • Philip C Bevilacqua
    Research
    Nature Chemical Biology
    Volume: 13, P: 439-445

  • Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4.

    • Nolan Kamitaki
    • Aswin Sekar
    • Steven A. McCarroll
    Research
    Nature
    Volume: 582, P: 577-581

  • RNA is central to many cellular functions, but in vivo structures of most RNAs are unknown. Here Kwok et al. present a universally applicable method, DMS/SHAPE-LMPCR, to identify structures of low-abundance transcripts in living cells, which reveals important features that are uniquely present in vivo.

    • Chun Kit Kwok
    • Yiliang Ding
    • Philip C Bevilacqua
    Research
    Nature Communications
    Volume: 4, P: 1-12

  • The biochemical roles and mechanisms of multiphase membraneless organelles are not yet well understood. Now, multiphase peptide droplets have been shown to sort RNA based on whether it is single- or double-stranded, as well as impact RNA duplexation through in-droplet thermodynamic equilibria. This work provides insight into possible primitive mechanisms for multicompartment intracellular condensates and can aid in the design of functional artificial membraneless organelles.

    • Saehyun Choi
    • McCauley O. Meyer
    • Christine D. Keating
    Research
    Nature Chemistry
    Volume: 14, P: 1110-1117

  • The RNA-activated protein kinase PKR inhibits translation initiation by sensing long viral double-stranded RNA. A new report indicates that PKR is also activated by a cellular mRNA, but only when ribosomes are not initiating translation.

    • Rebecca Toroney
    • Philip C Bevilacqua
    News & Views
    Nature Chemical Biology
    Volume: 5, P: 873-874

  • sc-SPORT offers a way to probe RNA structure at the single-cell level. It reveals cell-to-cell heterogeneity in RNA folding.

    • Elizabeth A. Jolley
    • Philip C. Bevilacqua
    News & Views
    Nature Methods
    Volume: 21, P: 377-378

  • Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

    • Russell L. McLaughlin
    • Dick Schijven
    • Michael C. O’Donovan
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • RNA structure is irrevocably linked to function. A new method, termed 'LASER', utilizes a light-activated chemical probe to query RNA tertiary structure and illuminate RNA–protein interactions in the living cell.

    • Philip C Bevilacqua
    • Sarah M Assmann
    News & Views
    Nature Chemical Biology
    Volume: 14, P: 200-201