Jones and colleagues combine lineage tracing experiments, chemical carcinogenesis assays and mathematical modelling to study field change development in a preneoplastic epithelium. They demonstrate that Notch pathway inhibition in oesophageal epithelial progenitor cells results in imbalanced differentiation, and mutant clone expansion and dominance in the epithelium, increasing the likelihood of transformation.
- Maria P. Alcolea
- Philip Greulich
- Philip H. Jones
