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Showing 1–10 of 10 results
Advanced filters: Author: Philip Hasel Clear advanced filters

  • How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocytic function; interestingly, many of these genes are dysregulated in neurodegeneration.

    • Philip Hasel
    • Owen Dando
    • Giles E. Hardingham
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • Using single-cell RNA sequencing and spatial transcriptomics, Hasel et al. uncover complex reactive astrocyte subtypes that occupy distinct areas of the brain. They find two super-responders expressing unique genes in strategic locations in the brain.

    • Philip Hasel
    • Indigo V. L. Rose
    • Shane A. Liddelow
    Research
    Nature Neuroscience
    Volume: 24, P: 1475-1487

  • Neurons in the brain are more susceptible to oxidative stress than astroglial cells but the molecular basis and biological reasons for this are poorly understood. Here the authors show that developing cortical neurons have reduced levels of the antioxidant transcription factor Nrf2 due to epigenetic silencing and that this is necessary for proper neuronal development.

    • Karen F.S. Bell
    • Bashayer Al-Mubarak
    • Giles E. Hardingham
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-15

  • Astrocytes can respond to diseases and injuries of the central nervous system by driving the death of neurons and mature oligodendrocytes through the delivery of long-chain saturated fatty acids contained in lipoparticles.

    • Kevin A. Guttenplan
    • Maya K. Weigel
    • Ben A. Barres
    Research
    Nature
    Volume: 599, P: 102-107

  • The concept of 'Embodied Energy'—in which the components of a robot or device both store energy and provide a mechanical or structural function—is put forward, along with specific robot-design principles.

    • Cameron A. Aubin
    • Benjamin Gorissen
    • Robert F. Shepherd
    Reviews
    Nature
    Volume: 602, P: 393-402

  • How the brain’s antioxidant defenses adapt to changing demand is not well understood. Here the authors demonstrate that synaptic activity is coupled to transcriptional control of the glutathione antioxidant system via NMDA receptors, enabling neurons to tune their antioxidant defenses.

    • Paul S. Baxter
    • Karen F.S. Bell
    • Giles E. Hardingham
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Apolipoprotein E (APOE) is the most abundant apolipoprotein in the brain, where it is primarily expressed and secreted by astrocytes and microglia. APOE seems to exert immunomodulatory effects in an isoform-dependent way, and a new study indicates that the APOE isoform dictates the glycosylation state and secretion of this apolipoprotein.

    • Philip Hasel
    • Shane A. Liddelow
    News & Views
    Nature Reviews Neurology
    Volume: 17, P: 265-266