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Showing 1–50 of 112 results
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  • A transition-metal-free platform enables the formation of challenging C(sp3)–C(sp3) bonds in organic compounds via single-electron transfer, facilitating the coupling of functionalized fragments and expanding possibilities for efficient organic synthesis and reaction design.

    • Sven Roediger
    • Emilien Le Saux
    • Bill Morandi
    ResearchOpen Access
    Nature
    Volume: 636, P: 108-114
  • The Fermi surface is related to the energy distribution of electrons in a solid, and governs physical properties of metals and semiconductors. A new type of angle-resolved photoemission spectroscopy, probing the Fermi surface and combining short recording time with high resolution, is now presented.

    • Sergey Borisenko
    • Alexander Fedorov
    • Bernd Büchner
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-6
  • Analysis of shallow-water marine carbonate samples from 101 stratigraphic units allows construction of a record of lithium isotopes from the past 3 billion years, tracking the evolution of the global carbon and silicon cycles.

    • Boriana Kalderon-Asael
    • Joachim A. R. Katchinoff
    • Philip A. E. Pogge von Strandmann
    Research
    Nature
    Volume: 595, P: 394-398
  • In somatic cells the mechanisms maintaining the chromosome ends are normally inactivated; however, cancer cells can re-activate these pathways to support continuous growth. Here, the authors characterize the telomeric landscapes across tumour types and identify genomic alterations associated with different telomere maintenance mechanisms.

    • Lina Sieverling
    • Chen Hong
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Integrative analyses of transcriptome and whole-genome sequencing data for 1,188 tumours across 27 types of cancer are used to provide a comprehensive catalogue of RNA-level alterations in cancer.

    • Claudia Calabrese
    • Natalie R. Davidson
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 129-136
  • The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 cancer whole genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

    • Lauri A. Aaltonen
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 82-93
  • In this study the authors consider the structural variants (SVs) present within cancer cases of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. They report hundreds of genes, including known cancer-associated genes for which the nearby presence of a SV breakpoint is associated with altered expression.

    • Yiqun Zhang
    • Fengju Chen
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14
  • With the generation of large pan-cancer whole-exome and whole-genome sequencing projects, a question remains about how comparable these datasets are. Here, using The Cancer Genome Atlas samples analysed as part of the Pan-Cancer Analysis of Whole Genomes project, the authors explore the concordance of mutations called by whole exome sequencing and whole genome sequencing techniques.

    • Matthew H. Bailey
    • William U. Meyerson
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-27
  • Understanding deregulation of biological pathways in cancer can provide insight into disease etiology and potential therapies. Here, as part of the PanCancer Analysis of Whole Genomes (PCAWG) consortium, the authors present pathway and network analysis of 2583 whole cancer genomes from 27 tumour types.

    • Matthew A. Reyna
    • David Haan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17
  • There’s an emerging body of evidence to show how biological sex impacts cancer incidence, treatment and underlying biology. Here, using a large pan-cancer dataset, the authors further highlight how sex differences shape the cancer genome.

    • Constance H. Li
    • Stephenie D. Prokopec
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-24
  • Analyses of 2,658 whole genomes across 38 types of cancer identify the contribution of non-coding point mutations and structural variants to driving cancer.

    • Esther Rheinbay
    • Morten Muhlig Nielsen
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 102-111
  • Whole-genome sequencing data from more than 2,500 cancers of 38 tumour types reveal 16 signatures that can be used to classify somatic structural variants, highlighting the diversity of genomic rearrangements in cancer.

    • Yilong Li
    • Nicola D. Roberts
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 112-121
  • Viral pathogen load in cancer genomes is estimated through analysis of sequencing data from 2,656 tumors across 35 cancer types using multiple pathogen-detection pipelines, identifying viruses in 382 genomic and 68 transcriptome datasets.

    • Marc Zapatka
    • Ivan Borozan
    • Christian von Mering
    ResearchOpen Access
    Nature Genetics
    Volume: 52, P: 320-330
  • Analysis of cancer genome sequencing data has enabled the discovery of driver mutations. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium the authors present DriverPower, a software package that identifies coding and non-coding driver mutations within cancer whole genomes via consideration of mutational burden and functional impact evidence.

    • Shimin Shuai
    • Federico Abascal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Whole-genome sequencing data for 2,778 cancer samples from 2,658 unique donors across 38 cancer types is used to reconstruct the evolutionary history of cancer, revealing that driver mutations can precede diagnosis by several years to decades.

    • Moritz Gerstung
    • Clemency Jolly
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 122-128
  • Some cancer patients first present with metastases where the location of the primary is unidentified; these are difficult to treat. In this study, using machine learning, the authors develop a method to determine the tissue of origin of a cancer based on whole sequencing data.

    • Wei Jiao
    • Gurnit Atwal
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • The authors present SVclone, a computational method for inferring the cancer cell fraction of structural variants from whole-genome sequencing data.

    • Marek Cmero
    • Ke Yuan
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15
  • Many tumours exhibit hypoxia (low oxygen) and hypoxic tumours often respond poorly to therapy. Here, the authors quantify hypoxia in 1188 tumours from 27 cancer types, showing elevated hypoxia links to increased mutational load, directing evolutionary trajectories.

    • Vinayak Bhandari
    • Constance H. Li
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10
  • Multi-omics datasets pose major challenges to data interpretation and hypothesis generation owing to their high-dimensional molecular profiles. Here, the authors develop ActivePathways method, which uses data fusion techniques for integrative pathway analysis of multi-omics data and candidate gene discovery.

    • Marta Paczkowska
    • Jonathan Barenboim
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16
  • The characterization of 4,645 whole-genome and 19,184 exome sequences, covering most types of cancer, identifies 81 single-base substitution, doublet-base substitution and small-insertion-and-deletion mutational signatures, providing a systematic overview of the mutational processes that contribute to cancer development.

    • Ludmil B. Alexandrov
    • Jaegil Kim
    • Christian von Mering
    ResearchOpen Access
    Nature
    Volume: 578, P: 94-101
  • Cancers evolve as they progress under differing selective pressures. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, the authors present the method TrackSig the estimates evolutionary trajectories of somatic mutational processes from single bulk tumour data.

    • Yulia Rubanova
    • Ruian Shi
    • Christian von Mering
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12
  • Cilia are hair-like protuberances on the cellular surface that have been implicated in sensing and signal transduction. Here Gerdes et al. show cilia are involved in insulin signalling and secretion in pancreatic β-cells of rodents, and suggest that ciliary dysfunction could contribute to type 2 diabetes.

    • Jantje M. Gerdes
    • Sonia Christou-Savina
    • Per-Olof Berggren
    Research
    Nature Communications
    Volume: 5, P: 1-13
  • A metastable pentagonal PdTe2 monolayer has been synthesized through symmetry-driven epitaxy, utilizing lattice matching with a Pd(100) substrate. The lattices, phonons and electronic structures of this phase have been studied.

    • Lina Liu
    • Yujin Ji
    • Yong P. Chen
    Research
    Nature Materials
    Volume: 23, P: 1339-1346
  • Although the valence and conduction electrons of a solid exist in states that extend throughout the solid, those of the innermost shells of its constituent atoms are usually considered to be strongly localized. A study of the photoelectron emission spectrum from graphene suggests that this isn’t always the case.

    • Silvano Lizzit
    • Guillermo Zampieri
    • Philip Hofmann
    Research
    Nature Physics
    Volume: 6, P: 345-349
  • A study on the subtle interplay between electronic structure and structural defects now explains why the suppression of conduction in the insulating state of bilayer graphene is not as strong as might be expected. It also reveals the possibility of creating graphene-based nanoscale systems with unique electronic properties.

    • Philip Hofmann
    News & Views
    Nature Materials
    Volume: 12, P: 874-875
  • Kramers nodal lines are doubly degenerate nodal lines connecting time-reversal invariant momenta, which are predicted to exist in achiral, non-centrosymmetric crystals with spin-orbit interactions. Here, the authors use ARPES and DFT to demonstrate signatures of Kramers nodal lines in a non-centrosymmetric charge density wave-hosting crystal.

    • Shuvam Sarkar
    • Joydipto Bhattacharya
    • Sudipta Roy Barman
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-11
  • Expression profiles of several hundred microRNAs in the blood of individuals with disease, including autoimmune disease, cancers, cardiovascular disease and chronic inflammatory disease are reported.

    • Andreas Keller
    • Petra Leidinger
    • Eckart Meese
    Research
    Nature Methods
    Volume: 8, P: 841-843
  • A plasmon of low energy that was therefore thought to be impossible to support on a metal surface is observed; the underlying bulk electrons would simply destroy it. It is found that this new plasmon, which has an acoustic, linear dispersion (energy dependence on momentum), can exist due to a particular, non-local aspect, of its energy structure.

    • Bogdan Diaconescu
    • Karsten Pohl
    • Mario Rocca
    Research
    Nature
    Volume: 448, P: 57-59
  • Several routes designed to induce a bandgap opening in graphene have been proposed. It is now demonstrated that hydrogen adsorption on the Moiré pattern induced by an iridium substrate can induce a bandgap of 450 meV.

    • Richard Balog
    • Bjarke Jørgensen
    • Liv Hornekær
    Research
    Nature Materials
    Volume: 9, P: 315-319
  • Graphene-dielectric interfaces play a crucial role in many electronic devices, but electronic properties of graphene are inevitably degraded when the interfaces are produced. Omiciuolo et al.solve this problem using a low-cost approach based on epitaxial growth of graphene on dielectric alloys.

    • Luca Omiciuolo
    • Eduardo R. Hernández
    • Alessandro Baraldi
    Research
    Nature Communications
    Volume: 5, P: 1-8
  • Knowledge of the spin structure in parent compounds of unconventional superconductors is crucial for an understanding of the complex physics in these materials. Here, the authors report canted spin structure on the surface as well as on the thin film form of Fe1+yTe, different from the bulk.

    • Torben Hänke
    • Udai Raj Singh
    • Roland Wiesendanger
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-8