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Showing 1–4 of 4 results
Advanced filters: Author: Philip Redpath Clear advanced filters

  • This study reports on excavations of hearths and stone artefacts from 20,000-year-old deposits at Dargan Shelter, which at an elevation of 1,073 m is believed to be the oldest occupied high-altitude site in Australia.

    • Amy M. Way
    • Philip J. Piper
    • Wayne Brennan
    ResearchOpen Access
    Nature Human Behaviour
    P: 1-9

  • Endocytosis of T cell receptors (TCR) and their polarized recycling back to the plasma membrane is crucial for T cell activation; however, the underlying mechanisms remain unclear. Here the authors follow TCR and show that a mobile endocytic network connects clathrin-independent receptor endocytosis to recycling which is required for T cell activation.

    • Ewoud B. Compeer
    • Felix Kraus
    • Jérémie Rossy
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • NAD+ is an important coenzyme that mediates cellular metabolism and defends against stresses due to age and overnutrition. Here the authors demonstrate unique bioavailability of the NAD+ precursor vitamin nicotinamide riboside (NR) in mice and humans, and show that NR safely elevates human NAD+.

    • Samuel A. J. Trammell
    • Mark S. Schmidt
    • Charles Brenner
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-14

  • Raising cellular levels of the metabolic cofactor NAD+ reverses key indicators of aging. Here, Ratajczak et al. show that cellular levels of NAD+ depend on the extracellular catalytic activity of NRK1, which processes two NAD+precursors, nicotinamide mononucleotide and nicotinamide riboside, in mice.

    • Joanna Ratajczak
    • Magali Joffraud
    • Carles Cantó
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12