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Showing 1–3 of 3 results
Advanced filters: Author: Philip V. Theodosopoulos Clear advanced filters

  • In patients with advanced cancer, the development of brain metastasis (BM) often signals a worsening prognosis with limited therapeutic options. Here, the authors assemble a large, open-source neuroimaging dataset of BM and perform spatial and morphological analysis which they use to develop a framework for function-sparing brain radiotherapy design.

    • Jorge Barrios
    • Evan Porter
    • Olivier Morin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Schwannomas are regularly treated with radiotherapy, but the molecular effects on these tumours and their microenvironment remain unclear. Here, the authors show that radiotherapy can induce epigenetic reprogramming and immune infiltration in schwannomas, and develop the snARC-seq approach to analyse the epigenomic evolution at the single-cell level.

    • S. John Liu
    • Tim Casey-Clyde
    • David R. Raleigh
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-19

  • Meningiomas are heterogeneous tumours. Here, the authors analysed genetic, epigenetic, and transcriptomic features across spatially-distinct meningioma samples to identify molecular programs underlying tumorigenesis that can be detected preoperatively using magnetic resonance imaging.

    • Stephen T. Magill
    • Harish N. Vasudevan
    • David R. Raleigh
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-15