The deubiquitylating enzyme ataxin 3 causes polyglutamine disease. In Caenorhabditis elegans, an ataxin-3 orthologue cooperates with the ubiquitin-selective chaperone CDC-48/p97 to control lifespan in a manner that may involve ubiquitin chain editing.
- Kirsten Kuhlbrodt
- Philipp Christoph Janiesch
- Thorsten Hoppe
