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Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions

The Caucasus mountain range has impacted on the culture and genetics of the wider region. Here, the authors generate genome-wide SNP data for 45 Eneolithic and Bronze Age individuals across the Caucasus, and find distinct genetic clusters between mountain and steppe zones as well as occasional gene-flow.

Chuan-Chao Wang
Sabine Reinhold
Wolfgang Haak
ResearchOpen Access04 Feb 2019
Nature Communications

Volume: 10, P: 1-13
CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid—a promising combination strategy for therapeutic intervention

Fatemeh Shokraie
Larissa Lechermeier
Claudia Maletzki
ResearchOpen Access02 Aug 2025
Cell Death Discovery

Volume: 11, P: 1-11
National Institutes of Health Stroke Scale (NIHSS) on admission predicts acute symptomatic seizure risk in ischemic stroke: a population-based study involving 135,117 cases

Johann Philipp Zöllner
Björn Misselwitz
Adam Strzelczyk
ResearchOpen Access02 Mar 2020
Scientific Reports

Volume: 10, P: 1-7
Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma

Thomas Freitag
Philipp Kaps
Claudia Maletzki
ResearchOpen Access25 Jul 2024
npj Precision Oncology

Volume: 8, P: 1-17
Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells

The complex effects of combined CDki/SPyADI application on arginine-auxotrophic glioblastoma multiforme cells. CDki/SPyADI combination therapy impairs cell proliferation, invasiveness, gene expression, induces mitochondrial impairment, and vacuole formation. Abemaciclib-SPyADI-treatment suppresses DNA repair, dinaciclib-SpyADI-treatment enhances γ-H2AX accumulation and activates the stress sensor GADD45 and β-catenin antagonist AXIN2. Both CDKi/SpyADI combinations significantly boost cell death.

Christin Riess
Katharina del Moral
Claudia Maletzki
ResearchOpen Access18 Jun 2022
Cell Death & Disease

Volume: 13, P: 1-14

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Ancient human genome-wide data from a 3000-year interval in the Caucasus corresponds with eco-geographic regions

CDK inhibitors promote neuroblastoma cell differentiation and increase sensitivity to retinoic acid—a promising combination strategy for therapeutic intervention

National Institutes of Health Stroke Scale (NIHSS) on admission predicts acute symptomatic seizure risk in ischemic stroke: a population-based study involving 135,117 cases

Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma

Implementation of a combined CDK inhibition and arginine-deprivation approach to target arginine-auxotrophic glioblastoma multiforme cells

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