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Showing 1–34 of 34 results
Advanced filters: Author: Phillip D Zamore Clear advanced filters

  • To determine long-range linkage between single-nucleotide polymorphisms (SNPs) and the repeat-containing region of a disease-related gene, Liu et al. develop SNP linkage by circularization (SLiC) and lay the groundwork for using allele-specific RNA interference to target insertion or deletion mutations in disease-associated genes.

    • Wanzhao Liu
    • Lori A Kennington
    • Neil Aronin
    Research
    Nature Methods
    Volume: 5, P: 951-953

  • Of the two types of Argonaute proteins produced by animals, AGO and PIWI, PIWI proteins can bind RNAs with less complementarity, enabling efficient silencing of transposons without the need to produce new RNA guides.

    • Ildar Gainetdinov
    • Joel Vega-Badillo
    • Phillip D. Zamore
    ResearchOpen Access
    Nature
    Volume: 619, P: 394-402

  • The evolutionarily conserved RNA-binding protein GTSF1 and its homologues interact with members of the PIWI class of Argonaute proteins, increasing the efficiency of the RNA-cleaving activity of PIWI proteins, an essential function across the animal kingdom.

    • Amena Arif
    • Shannon Bailey
    • Phillip D. Zamore
    ResearchOpen Access
    Nature
    Volume: 608, P: 618-625

  • Two studies in nematodes revolutionized our understanding of gene regulation by identifying and functionally characterizing the first microRNA, lin-4.

    • Phillip D. Zamore
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 21, P: 565

  • Analysis of single-molecule binding assays still requires substantial manual user intervention. Here, the authors present a pipeline for rapid, automated analysis of co-localization single-molecule spectroscopy images, with a modular user interface that can be adjusted to a range of experimental conditions.

    • Carlas S. Smith
    • Karina Jouravleva
    • David Grunwald
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-9

  • Wu and Zamore discuss models of piRNA function and suggest experimental criteria to be followed in order to validate them.

    • Pei-Hsuan Wu
    • Phillip D. Zamore
    Comments & Opinion
    Nature Reviews Molecular Cell Biology
    Volume: 22, P: 239-240

  • The mechanisms that regulate miRNA stability and the generation of distinct miRNA isoforms are beginning to be elucidated. Better understanding of how such miRNAs mediate gene expression control will require quantitative analyses that dissect different models of miRNA function.

    • Stefan L. Ameres
    • Phillip D. Zamore
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 14, P: 475-488

  • In fruit flies, a few very large genes generate the small RNAs that silence parasitic DNA elements. These RNAs might also participate in an amplification circuit that increases their potency.

    • Phillip D. Zamore
    News & Views
    Nature
    Volume: 446, P: 864-865

  • Small RNAs — including miRNAs, siRNAs and piRNAs — differ in their biogenesis, modes of target regulation and biological functions. There are also interconnections between these pathways, which compete and collaborate in some of their regulatory and protective roles.

    • Megha Ghildiyal
    • Phillip D. Zamore
    Reviews
    Nature Reviews Genetics
    Volume: 10, P: 94-108

  • Tough decoy microRNA inhibitor, shown to be the most effective of several designs, is packaged in recombinant adeno-associated virus and used for prolonged microRNA inhibition in living mice. A single injection effectively reduces miR-122 in the liver and serum cholesterol for at least 25 weeks.

    • Jun Xie
    • Stefan L Ameres
    • Guangping Gao
    Research
    Nature Methods
    Volume: 9, P: 403-409

  • MicroRNAs (miRNAs) repress target mRNAs, often with exquisite tissue specificity. Wang et al. exploit the specific expression of miRNAs to regulate guide production for Cas9. Their method enables novel strategies to simultaneously measure the activity of multiple miRNAs and restrict Cas9 binding or genome editing to precisely defined cell types.

    • Karina Jouravleva
    • Phillip D. Zamore
    News & Views
    Nature Cell Biology
    Volume: 21, P: 416-417

  • Many new small RNA species and their derived fragments have been recently identified in animals. This Review discusses the biogenesis and functions of both structural small RNAs, such as tRNAs and small nuclear RNAs (snRNAs), and of regulatory small RNAs such as microRNAs and PIWI-interacting RNAs (piRNAs).

    • Karina Jouravleva
    • Phillip D. Zamore
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 347-370

  • The power of small RNAs to shut down specific gene activities has now been brought to bear on an animal model of hepatitis. Mice infused with an siRNA against a cell death receptor recover liver function after experimentally induced injury (pages 347–351).

    • Phillip D. Zamore
    • Neil Aronin
    News & Views
    Nature Medicine
    Volume: 9, P: 266-267

  • Flies use master lists of DNA sequences from transposons to identify and silence these virus-like, genomic parasites. How the lists themselves escape the fate of their transposon targets has now been solved. See Letter p.54

    • Phillip D. Zamore
    News & Views
    Nature
    Volume: 549, P: 38-39

  • PIWI-interacting RNAs (piRNAs) have numerous crucial biological roles, particularly transposon silencing in the germ line. In this Review, the authors describe our latest understanding of piRNA biogenesis and functions across diverse species, highlighting how, despite the universal importance of transposon control, different species have evolved intriguingly distinct mechanistic routes to achieve this.

    • Deniz M. Ozata
    • Ildar Gainetdinov
    • Phillip D. Zamore
    Reviews
    Nature Reviews Genetics
    Volume: 20, P: 89-108

  • The family of Argonaute proteins has important roles in RNA-mediated gene silencing. Argonaute proteins form complexes with small non-coding RNAs such as small interfering RNAs and microRNAs, control protein synthesis and mRNA stability, and participate in the production of a new class of small RNAs, Piwi-interacting RNAs.

    • Gyorgy Hutvagner
    • Martin J. Simard
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 9, P: 22-32