Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–9 of 9 results
Advanced filters: Author: Phillip G. Popovich Clear advanced filters

  • Spinal cord injury (SCI) often leads to immune dysfunction, but mechanistic insights are still lacking. Here the authors show that SCI alters chemokine signaling and induces long, persisting defects in hematopoietic stem and progenitor cell migration, thereby entrapping them in the bone marrow and disrupting peripheral immune homeostasis.

    • Randall S. Carpenter
    • Jessica M. Marbourg
    • Phillip G. Popovich
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13

  • A growing field of neuroscience aims to understand how immune responses can promote CNS repair. Popovich and Longbrake discuss current approaches to manipulate neuroimmune interactions and give their opinion on the challenges ahead.

    • Phillip G. Popovich
    • Erin E. Longbrake
    Reviews
    Nature Reviews Neuroscience
    Volume: 9, P: 481-493

  • In neonatal mice, scar-free healing after spinal cord injury is organized by microglia, and transplantation of neonatal microglia or peptidase-inhibitor-treated adult microglia into adult mice after injury improves healing and axon regrowth.

    • Yi Li
    • Xuelian He
    • Zhigang He
    Research
    Nature
    Volume: 587, P: 613-618

  • The authors document a novel neurogenic mechanism to explain the clinical syndrome known as spinal cord injury–induced immune deficiency. Specifically, they show that new spinal–splenic sympathetic circuitry forms below the level of injury, creating an exaggerated sympathetic anti-inflammatory reflex. Inhibiting excitatory interneurons within this circuitry blocks immune suppression.

    • Masaki Ueno
    • Yuka Ueno-Nakamura
    • Yutaka Yoshida
    Research
    Nature Neuroscience
    Volume: 19, P: 784-787

  • In this Perspective, the authors discuss the mechanisms underlying the complex relationship between lesion size and functional recovery after spinal cord injury, highlighting various complications that can limit the accuracy of outcome prediction in patients and in animal models.

    • Karim Fouad
    • Phillip G. Popovich
    • Jan M. Schwab
    Reviews
    Nature Reviews Neurology
    Volume: 17, P: 53-62