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Showing 1–3 of 3 results
Advanced filters: Author: Phillip Ordoukhanian Clear advanced filters

  • Single-cell RNAseq can struggle to capture cellular heterogeneity due to the relatively low expression of biologically meaningful transcripts. Here the authors present an approach called scCLEAN, which uses CRISPR/Cas9 to target and remove certain ubiquitous transcripts, thereby enhancing the detection of low-abundance transcripts.

    • Amitabh C. Pandey
    • Jon Bezney
    • Eric J. Topol
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-17

  • Many efforts to expand the genetic alphabet and reprogram the genetic code have relied on synthetic DNA nucleotides designed to have pairing properties orthogonal to those of natural base pairs. A structural study shows that DNA polymerases enhance the efficiency of non-natural base pair replication by enforcing a standard Watson-Crick geometry in the polymerase active site.

    • Karin Betz
    • Denis A Malyshev
    • Andreas Marx
    Research
    Nature Chemical Biology
    Volume: 8, P: 612-614