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Showing 1–5 of 5 results
Advanced filters: Author: Phillip Pymm Clear advanced filters

  • Human leukocyte antigens (HLA) are multi-allelic and polymorphic genes that present antigens to immune cells for inducing protective immunity. Here, using systems biology and structural approaches, the authors show that micropolymorphism of three HLA has effects beyond the modulation of antigen diversity.

    • Patricia T. Illing
    • Phillip Pymm
    • Anthony W. Purcell
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • Structural determination and analysis of HLA-I that presents an HIV-derived peptide to an NK cell receptor reveal that N-terminal extended epitope conformations contribute to immune recognition and mechanisms of HIV immune escape.

    • Phillip Pymm
    • Patricia T Illing
    • Julian P Vivian
    Research
    Nature Structural & Molecular Biology
    Volume: 24, P: 387-394

  • KIR2DL2 and KIR2DL3 are two inhibitory members of the killer-cell immunoglobulin-like receptors (KIR) family that share a common HLA-I preference in binding HLA from the C1 group. However, it is still unclear to what extent binding and function is equivalent between KIR2DL2 and 2DL3. Here, the authors present the crystal structures of KIR2DL2 and 2DL3 in complex with HLA-C*07:02 and observe differences in HLA-C recognition between KIR2DL2 and 2DL3, which correlates with differences in HLA-C binding preference as they show with mutagenesis and binding studies.

    • Shoeib Moradi
    • Sanda Stankovic
    • Julian P. Vivian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • In a cohort of recovered patients with COVID-19, virus spike-specific antibodies were consistently elicited, but neutralizing activity was highly variable and inversely correlated with the proportion of CCR6+CXCR3− spike-specific circulating follicular helper T cells.

    • Jennifer A. Juno
    • Hyon-Xhi Tan
    • Adam K. Wheatley
    Research
    Nature Medicine
    Volume: 26, P: 1428-1434