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Showing 1–3 of 3 results
Advanced filters: Author: Pierre Bourdely Clear advanced filters

  • Response to immune checkpoint inhibitors (ICIs) in patients with non-small cell lung cancer (NSCLC) remains suboptimal, even for tumors with elevated tumor mutational burden. Here the authors generate a model of NSCLC with enhanced mutational load, showing that, while still resistant to ICIs, hypermutated tumors become sensitive to dendritic cell-targeted therapy.

    • Lucía López
    • Luciano Gastón Morosi
    • Federica Benvenuti
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Classical human dendritic cells (cDCs) are rare sentinel cells specialized in regulating adaptive immunity. Here, the authors show that expression of membrane bound FLT3L, along with stem cell factor (SCF) and CXCL12 in stromal cells induces specification of pre/AS-DCs, type 1 and type2 cDC from haematopoietic stem cells.

    • Giorgio Anselmi
    • Kristine Vaivode
    • Pierre Guermonprez
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-18