Nature Search

Prednisone Increases the Number of Insulin Receptors in Erythrocytes from Children

Bertrand Canivet
Claudine Poustis-Delpont
Pierre Freychet
Research01 Aug 1983
Pediatric Research

Volume: 17, P: 672-675
How ligand binds to the type 1 insulin-like growth factor receptor

The human type 1 insulin-like growth factor receptor (IGF-1R) is important for normal human growth and development. Here, the authors present the crystal structures of the IGF-1R ectodomain both in its apo form and in complex with its ligand insulin-like growth factor I and discuss the receptor activation mechanism.

Yibin Xu
Geoffrey K.-W. Kong
Michael C. Lawrence
ResearchOpen Access26 Feb 2018
Nature Communications

Volume: 9, P: 1-13
Structural biology of insulin and IGF1 receptors: implications for drug design

Pierre De Meyts
Jonathan Whittaker
Reviews01 Oct 2002
Nature Reviews Drug Discovery

Volume: 1, P: 769-783
Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Insulin hormones and their receptors regulate key life processes in animals: from metabolism to life span. Human insulin receptor has been studied extensively. Here, the authors show remarkable structural similarity of fruit fly and human insulin receptors, indicating their universal functioning.

Cristina M. Viola
Orsolya Frittmann
Andrzej M. Brzozowski
ResearchOpen Access07 Oct 2023
Nature Communications

Volume: 14, P: 1-13
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Structural basis for the poisonous activity of a predator's venom insulin

A potent toxin present in the venom of a fish-hunting cone snail is a minimized insulin (Con-Ins G1) lacking key residues involved in the receptor binding of most insulins. New data show that Con-Ins G1 nevertheless binds potently to the human insulin receptor, owing to a rearrangement that compensates for the lack of a critical binding residue.

Pierre De Meyts
News & Views05 Oct 2016
Nature Structural & Molecular Biology

Volume: 23, P: 872-874
Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

Insulin-like polypeptide binding proteins (IBPs) from insects can bind diverse insulin-like proteins (ILPs) including human insulin and IGFs. Here, the authors present structures of a Drosophila IBP in its free and ILP-bound forms, providing insights into the regulation of ILP bioavailability by insect IBPs.

Nikolaj Kulahin Roed
Cristina M. Viola
Andrzej M. Brzozowski
ResearchOpen Access21 Sept 2018
Nature Communications

Volume: 9, P: 1-12
Human genetic and immunological determinants of critical COVID-19 pneumonia

The COVID Human Genetic Effort examines the molecular, cellular and immunological determinants of the various SARS-CoV-2-related disease manifestations by searching for causal errors of immunity.

Qian Zhang
Paul Bastard
Jean-Laurent Casanova
Reviews28 Jan 2022
Nature

Volume: 603, P: 587-598
Mitogenic and Antiadipogenic Properties of Human Growth Hormone in Differentiating Human Adipocyte Precursor Cells in Primary Culture

Martin Wabitsch
Steffen Braun
Walter M Teller
Research01 Sept 1996
Pediatric Research

Volume: 40, P: 450-456
Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome

Ken McElreavey
Anne Jorgensen
Anu Bashamboo
ResearchOpen Access24 Jul 2019
Genetics in Medicine

Volume: 22, P: 150-159

Search

Prednisone Increases the Number of Insulin Receptors in Erythrocytes from Children

How ligand binds to the type 1 insulin-like growth factor receptor

Structural biology of insulin and IGF1 receptors: implications for drug design

Structural conservation of insulin/IGF signalling axis at the insulin receptors level in Drosophila and humans

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Structural basis for the poisonous activity of a predator's venom insulin

Structures of insect Imp-L2 suggest an alternative strategy for regulating the bioavailability of insulin-like hormones

Human genetic and immunological determinants of critical COVID-19 pneumonia

Mitogenic and Antiadipogenic Properties of Human Growth Hormone in Differentiating Human Adipocyte Precursor Cells in Primary Culture

Pathogenic variants in the DEAH-box RNA helicase DHX37 are a frequent cause of 46,XY gonadal dysgenesis and 46,XY testicular regression syndrome

Search

Quick links

Search

Filter By:

Search

Quick links